TY - JOUR
T1 - Increased neutralization capacity of TNF-α in sera of relapsing remitting multiple sclerosis patients is not related to soluble TNF-α receptors or anti-TNF-α autoantibody levels
AU - Mausner-Fainberg, Karin
AU - Regev, Keren
AU - Kolb, Hadar
AU - Vaknin-Dembinsky, Adi
AU - Karni, Arnon
N1 - Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2015/9/15
Y1 - 2015/9/15
N2 - The increased TNF-α levels in active lesions and CSF of multiple sclerosis (MS) patients and the beneficial effect of TNF-α blockade in animal models of MS led to the therapeutic usage of TNF-α antagonists. However, systemic TNF-α blockade exacerbated MS activity and was associated with new-onset MS when implemented for treating other autoimmune disorders. We employed a TNF-α neutralization bioassay and demonstrated that the capacity of sera from untreated and IFN-β-treated relapsing remitting MS patients to neutralize TNF-α is significantly higher than that of matched healthy controls. This finding was not related to sTNFRI, sTNFRII, or anti-TNF-α Abs levels.
AB - The increased TNF-α levels in active lesions and CSF of multiple sclerosis (MS) patients and the beneficial effect of TNF-α blockade in animal models of MS led to the therapeutic usage of TNF-α antagonists. However, systemic TNF-α blockade exacerbated MS activity and was associated with new-onset MS when implemented for treating other autoimmune disorders. We employed a TNF-α neutralization bioassay and demonstrated that the capacity of sera from untreated and IFN-β-treated relapsing remitting MS patients to neutralize TNF-α is significantly higher than that of matched healthy controls. This finding was not related to sTNFRI, sTNFRII, or anti-TNF-α Abs levels.
KW - Anti-TNF-α autoantibodies
KW - Multiple sclerosis
KW - Soluble TNF receptors
KW - TNF-α neutralization
KW - Tumor necrosis factor α
UR - http://www.scopus.com/inward/record.url?scp=84939478018&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2015.07.005
DO - 10.1016/j.jneuroim.2015.07.005
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C2 - 26298329
AN - SCOPUS:84939478018
SN - 0165-5728
VL - 286
SP - 83
EP - 85
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
ER -