@article{a3726452b46b41439288ee556778fd5b,
title = "Increased levels of acetylcholine receptor α-subunit mRNA in experimental autoimmune myasthenia gravis",
abstract = "To gain insight into the regulatory mechanisms underlying the blockade and loss of acetylcholine receptor (AChR) in myasthenia, we have followed AChR α-subunit mRNA levels in leg muscles of myasthenic and normal rabbits and rats. Northern blots of RNA preparations from normal and myasthenic animals were hybridized with a mouse AChR α-subunit cDNA probe. Our experiments indicate a specific increase (4-7-fold) in the levels of α-subunit mRNA in animals with experimental autoimmune myasthenia gravis (EAMG), in comparison with control animals. Actin mRNA levels were essentially unchanged. Our results thus suggest that EAMG is accompanied by an increased level of AChR gene transcription.",
keywords = "Acetylcholine receptor, Experimental autoimmune myasthenia gravis, mRNA",
author = "Orna Asher and Drorit Neumann and Sara Fuchs",
note = "Funding Information: Acknowledgements:W e thank D. Barchan for excellent technical assistancea nd Dr S. Heinemann for the gift of plasmid pMARl5. This research was supported by grants from the Muscular Dystrophy Association of America and the Los Angeles Chapter of the Myasthenia Gravis Foundation.",
year = "1988",
month = jun,
day = "20",
doi = "10.1016/0014-5793(88)80442-3",
language = "אנגלית",
volume = "233",
pages = "277--281",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Wiley-Blackwell",
number = "2",
}