Increased interleukin-1 and interleukin-3 like activity in schizophrenic patients

Pinkhas Sirota, Klara Schild, Avner Elizur, Meir Djaldetti, Pnina Fishman

Research output: Contribution to journalArticlepeer-review

Abstract

1. 1. The interleukins play an important role in the development and maintenance of the immune system 2. 2. Decreased cell mediated immunity measures were found in schizophrenic patients. 3. 3. The purpose of the present study was to study the spontaneous production of interleukin-1 (IL-1) and interleukin-3 like activity (IL-3-LA) by human mononuclear cells from schizophrenic patients in comparison to healthy individuals. 4. 4. Interleukin-1 was increased significant by schizophrenic patients as compared to controls. 5. 5. Interleukin-3 like activity was sligthly elevated in schizophrenic patients as compared to controls. 6. 6. These findings support the hypothesis of an autoimmune dysfunction in some schizophrenic patients.

Original languageEnglish
Pages (from-to)75-83
Number of pages9
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume19
Issue number1
DOIs
StatePublished - Jan 1995

Keywords

  • Autoimmunity
  • interleukin-1
  • interleukin-3 like activity
  • schizophrenia

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