The interleukins play an important role in the development and maintenance of the immune system. Decreased cell mediated immunity measures were found in schizophrenic patients. The purpose of the present study was to investigate the spontaneous, production of interleukin 1 (IL-3) and interteukin-3-like activity (IL-3-LA) by human mononuclear cells from schizophrenic patients compared to healthy individuals. IL-1 was significantly increased in schizophrenic patients as compared to controls. IL-3-LA was slightly elevated in schizophrenic patients as compared to controls. These findings support the hypothesis of an autoimmune dysfunction in some schizophrenic patients.
|Journal||Human Antibodies and Hybridomas|
|State||Published - 1996|