Increased apoptosis in patients with major depression: A preliminary study

Eran Eilat, Shlomo Mendlovic*, Adiel Doron, Vera Zakuth, Zvi Spirer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Apoptosis is a programmed cell death that can be observed in normal cells. Major depression poses a combination of a depressed and destructive autoimmune reaction. We measured apoptosis in the PBLs of seven patients with major depression and in age- and sex-matched controls. We observed significantly increased apoptosis in the PBLs of depressive patients (p < 0.05). These preliminary results could contribute to an understanding of the interactions of the CNS with the immune system, which could lead to the increased vulnerability of the CNS in depressive disorders. Further studies are needed to establish these results.

Original languageEnglish
Pages (from-to)533-534
Number of pages2
JournalJournal of Immunology
Issue number1
StatePublished - 1 Jul 1999


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