Abstract
This study shows a positive, significant correlation between the activity of porphobilinogen deaminase, one of the enzymes of the heme biosynthetic pathway, and the process of cellular transformation. Increased porphobilinogen deaminase activity was observed in mouse malignant lymphoid cell lines and rodent fibroblastic cell lines transformed by different strains of Moloney leukemia virus. These findings are of significance considering the increased activity of porphobilinogen deaminase in erythrocytes and lymphocytes of patients with malignant lymphoproliferative disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 627-629 |
| Number of pages | 3 |
| Journal | Medical Science Research |
| Volume | 16 |
| Issue number | 12 |
| State | Published - 1988 |
