Increased activity of porphobilinogen deaminase in Moloney leukemia virus transformed cells

Y. Teitz, N. Schoenfeld, O. Epstein, A. Atsmon

Research output: Contribution to journalArticlepeer-review

Abstract

This study shows a positive, significant correlation between the activity of porphobilinogen deaminase, one of the enzymes of the heme biosynthetic pathway, and the process of cellular transformation. Increased porphobilinogen deaminase activity was observed in mouse malignant lymphoid cell lines and rodent fibroblastic cell lines transformed by different strains of Moloney leukemia virus. These findings are of significance considering the increased activity of porphobilinogen deaminase in erythrocytes and lymphocytes of patients with malignant lymphoproliferative disorders.

Original languageEnglish
Pages (from-to)627-629
Number of pages3
JournalMedical Science Research
Volume16
Issue number12
StatePublished - 1988

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