Increase rate of ruptured tubal ectopic pregnancy during the COVID-19 pandemic

Shira Dvash, Howard Cuckle, Noam Smorgick, Zvi Vaknin, Anna Padoa, Ron Maymon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: During the 2020 COVID-19 pandemic there was a decrease in emergency room arrivals. There is limited evidence about the effect of this change in behavior on women's health. We aimed to evaluate the impact of the COVID-19 pandemic on the diagnosis, treatment and complications of women presenting with a tubal Ectopic Pregnancy (EP). Study design: This is a single centre retrospective cohort study. We compared the clinical presentation, treatment modalities and complications of all women presenting in our institution with a tubal EP during the COVID-19 pandemic between 15 March and 15 June 2020, with women who were treated in our institution with the same diagnosis in the corresponding period for the years 2018–2019. Results: The study group included 19 cases of EP (N = 19) that were treated between the 15 March 2020 and 15 June 2020. The control group included 30 cases of EP (N = 30) that were admitted to in the corresponding period during 2018 and 2019. Maternal age, parity, gravity and mode of conception (natural vs. assisted) were similar between the two groups. There was no difference in the mean gestational age (GA) according to the last menstrual period. In the study group more women presented with sonographic evaluation of high fluid volume in the abdomen than in the control group (53 % vs 17 %, P value 0.01). This finding is correlated with a more advanced disease status. In the study group there was a highly statistically significant 3-fold increase in rupture among cases (P < 0.005) and a 4-fold larger volume of blood in the entrance to the abdomen (P < 0.002). We found that there were no cases of ruptured EP in the group of women who were pregnant after assisted reproduction. Conclusion: We found a higher rate of ruptured ectopic pregnancies in our institution during the COVID-19 pandemic. Health care providers should be alerted to this collateral damage in the non-infected population during the COVID-19 pandemic.

Original languageEnglish
Pages (from-to)95-99
Number of pages5
JournalEuropean Journal of Obstetrics, Gynecology and Reproductive Biology
StatePublished - Apr 2021


  • COVID 19
  • Ectopic pregnancy
  • Lockdown
  • Methotrexate
  • Pandemic


Dive into the research topics of 'Increase rate of ruptured tubal ectopic pregnancy during the COVID-19 pandemic'. Together they form a unique fingerprint.

Cite this