@article{31698eb8349e412c80c855a75d706e62,
title = "Increase in power of transmission-disequilibrium tests for quantitative traits",
abstract = "Allison ([1997] Am. J. Hum. Genet. 60:676-690) proposed four versions of the transmission-disequilibrium test (TDT) for quantitative traits when there is extreme-threshold sampling, i.e., the trios having an offspring trait value between a priori defined thresholds are excluded from the analysis. Keeping intact the ideology and construction of these tests, we propose here an extreme-offspring design for the trios: for each parent pair of which at least one is heterozygous at a marker locus, the offspring having the most extreme trait value is selected for the trio. Our simulation studies show that the effect of the extreme-offspring design can be quite substantial (up to 30% increase in test power), and that the increase is greater for smaller values of the association parameter and for traits with smaller heritability: just those cases where the increase in power is especially desirable.",
keywords = "Extreme sampling, Quantitative traits, TDT power",
author = "Ida Malkin and Emil Ginsburg and Elston, {Robert C.}",
year = "2002",
month = oct,
doi = "10.1002/gepi.10180",
language = "אנגלית",
volume = "23",
pages = "234--244",
journal = "Genetic Epidemiology",
issn = "0741-0395",
publisher = "Wiley-Liss Inc.",
number = "3",
}