Increase in central and peripheral benzodiazepine receptors following surgery

Faina Okun; Ronit Weizman; Yeshayahu Katz; Arieh Bomzon; Moussa B.H. Youdim; Moshe Gavish

doi:10.1016/0006-8993(88)90492-1

Increase in central and peripheral benzodiazepine receptors following surgery

Faina Okun, Ronit Weizman, Yeshayahu Katz, Arieh Bomzon, Moussa B.H. Youdim, Moshe Gavish^*

^*Corresponding author for this work

Clinical Departments

Technion-Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

[³H]Flunitrazepam, [³H]PK 11195, [³H]quinuclidinyl benzilate (QNB) and monoamine oxidase (MAO) A and B activity were measured in male rats 1, 3 and 7 days following laparotomy. The surgery resulted in the up-regulation of central benzodiazepine (BZ) receptors in cerebral cortex and of peripheral BZ binding sites in brain and kidney of the first and third days after operation. This increase was followed by a decrease to normal range 7 days after the surgical procedure. [³H]QNB binding to muscarinic receptors in the cerebral cortex as well as MAO A and B activity in rat cerebral cortex and kidney were not affected by the surgical manipulation. The modulatory effect of surgery on BZ receptors corresponds to stages of the healing process in surgical wounds.

Original language	English
Pages (from-to)	31-36
Number of pages	6
Journal	Brain Research
Volume	458
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(88)90492-1
State	Published - 16 Aug 1988

Keywords

Central benzodiazepine receptor
Flunitrazepam
Ketamine
PK 11195
Peripheral benzodiazepine binding site
Stress
Surgery

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10.1016/0006-8993(88)90492-1

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title = "Increase in central and peripheral benzodiazepine receptors following surgery",

abstract = "[3H]Flunitrazepam, [3H]PK 11195, [3H]quinuclidinyl benzilate (QNB) and monoamine oxidase (MAO) A and B activity were measured in male rats 1, 3 and 7 days following laparotomy. The surgery resulted in the up-regulation of central benzodiazepine (BZ) receptors in cerebral cortex and of peripheral BZ binding sites in brain and kidney of the first and third days after operation. This increase was followed by a decrease to normal range 7 days after the surgical procedure. [3H]QNB binding to muscarinic receptors in the cerebral cortex as well as MAO A and B activity in rat cerebral cortex and kidney were not affected by the surgical manipulation. The modulatory effect of surgery on BZ receptors corresponds to stages of the healing process in surgical wounds.",

keywords = "Central benzodiazepine receptor, Flunitrazepam, Ketamine, PK 11195, Peripheral benzodiazepine binding site, Stress, Surgery",

author = "Faina Okun and Ronit Weizman and Yeshayahu Katz and Arieh Bomzon and Youdim, {Moussa B.H.} and Moshe Gavish",

note = "Funding Information: This study was supported in part by a grant from the Fund for Promotion of Research at the Technion. We thank Miss Ruth Singer for typing the manuscript.",

year = "1988",

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doi = "10.1016/0006-8993(88)90492-1",

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AU - Okun, Faina

AU - Weizman, Ronit

AU - Katz, Yeshayahu

AU - Bomzon, Arieh

AU - Youdim, Moussa B.H.

AU - Gavish, Moshe

N1 - Funding Information: This study was supported in part by a grant from the Fund for Promotion of Research at the Technion. We thank Miss Ruth Singer for typing the manuscript.

PY - 1988/8/16

Y1 - 1988/8/16

N2 - [3H]Flunitrazepam, [3H]PK 11195, [3H]quinuclidinyl benzilate (QNB) and monoamine oxidase (MAO) A and B activity were measured in male rats 1, 3 and 7 days following laparotomy. The surgery resulted in the up-regulation of central benzodiazepine (BZ) receptors in cerebral cortex and of peripheral BZ binding sites in brain and kidney of the first and third days after operation. This increase was followed by a decrease to normal range 7 days after the surgical procedure. [3H]QNB binding to muscarinic receptors in the cerebral cortex as well as MAO A and B activity in rat cerebral cortex and kidney were not affected by the surgical manipulation. The modulatory effect of surgery on BZ receptors corresponds to stages of the healing process in surgical wounds.

AB - [3H]Flunitrazepam, [3H]PK 11195, [3H]quinuclidinyl benzilate (QNB) and monoamine oxidase (MAO) A and B activity were measured in male rats 1, 3 and 7 days following laparotomy. The surgery resulted in the up-regulation of central benzodiazepine (BZ) receptors in cerebral cortex and of peripheral BZ binding sites in brain and kidney of the first and third days after operation. This increase was followed by a decrease to normal range 7 days after the surgical procedure. [3H]QNB binding to muscarinic receptors in the cerebral cortex as well as MAO A and B activity in rat cerebral cortex and kidney were not affected by the surgical manipulation. The modulatory effect of surgery on BZ receptors corresponds to stages of the healing process in surgical wounds.

KW - Central benzodiazepine receptor

KW - Flunitrazepam

KW - Ketamine

KW - PK 11195

KW - Peripheral benzodiazepine binding site

KW - Stress

KW - Surgery

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JF - Brain Research

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Increase in central and peripheral benzodiazepine receptors following surgery

Abstract

Keywords

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