Increase in central and peripheral benzodiazepine receptors following surgery

Faina Okun, Ronit Weizman, Yeshayahu Katz, Arieh Bomzon, Moussa B.H. Youdim, Moshe Gavish

Research output: Contribution to journalArticlepeer-review


[3H]Flunitrazepam, [3H]PK 11195, [3H]quinuclidinyl benzilate (QNB) and monoamine oxidase (MAO) A and B activity were measured in male rats 1, 3 and 7 days following laparotomy. The surgery resulted in the up-regulation of central benzodiazepine (BZ) receptors in cerebral cortex and of peripheral BZ binding sites in brain and kidney of the first and third days after operation. This increase was followed by a decrease to normal range 7 days after the surgical procedure. [3H]QNB binding to muscarinic receptors in the cerebral cortex as well as MAO A and B activity in rat cerebral cortex and kidney were not affected by the surgical manipulation. The modulatory effect of surgery on BZ receptors corresponds to stages of the healing process in surgical wounds.

Original languageEnglish
Pages (from-to)31-36
Number of pages6
JournalBrain Research
Issue number1
StatePublished - 16 Aug 1988


  • Central benzodiazepine receptor
  • Flunitrazepam
  • Ketamine
  • PK 11195
  • Peripheral benzodiazepine binding site
  • Stress
  • Surgery


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