@article{ce9d74cc6ec54ffb86dcc8834adbf3fc,
title = "Increase in central and peripheral benzodiazepine receptors following surgery",
abstract = "[3H]Flunitrazepam, [3H]PK 11195, [3H]quinuclidinyl benzilate (QNB) and monoamine oxidase (MAO) A and B activity were measured in male rats 1, 3 and 7 days following laparotomy. The surgery resulted in the up-regulation of central benzodiazepine (BZ) receptors in cerebral cortex and of peripheral BZ binding sites in brain and kidney of the first and third days after operation. This increase was followed by a decrease to normal range 7 days after the surgical procedure. [3H]QNB binding to muscarinic receptors in the cerebral cortex as well as MAO A and B activity in rat cerebral cortex and kidney were not affected by the surgical manipulation. The modulatory effect of surgery on BZ receptors corresponds to stages of the healing process in surgical wounds.",
keywords = "Central benzodiazepine receptor, Flunitrazepam, Ketamine, PK 11195, Peripheral benzodiazepine binding site, Stress, Surgery",
author = "Faina Okun and Ronit Weizman and Yeshayahu Katz and Arieh Bomzon and Youdim, \{Moussa B.H.\} and Moshe Gavish",
note = "Funding Information: This study was supported in part by a grant from the Fund for Promotion of Research at the Technion. We thank Miss Ruth Singer for typing the manuscript.",
year = "1988",
month = aug,
day = "16",
doi = "10.1016/0006-8993(88)90492-1",
language = "אנגלית",
volume = "458",
pages = "31--36",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier B.V.",
number = "1",
}