@article{a911168204dc48d38af81a66faa9e929,
title = "Incidence of cancer and overall risk of mortality in individuals treated with raltegravir-based and non-raltegravir-based combination antiretroviral therapy regimens",
abstract = "Objectives: There are currently few data on the long-term risk of cancer and death in individuals taking raltegravir (RAL). The aim of this analysis was to evaluate whether there is evidence for an association. Methods: The EuroSIDA cohort was divided into three groups: those starting RAL-based combination antiretroviral therapy (cART) on or after 21 December 2007 (RAL); a historical cohort (HIST) of individuals adding a new antiretroviral (ARV) drug (not RAL) to their cART between 1 January 2005 and 20 December 2007, and a concurrent cohort (CONC) of individuals adding a new ARV drug (not RAL) to their cART on or after 21 December 2007. Baseline characteristics were compared using logistic regression. The incidences of newly diagnosed malignancies and death were compared using Poisson regression. Results: The RAL cohort included 1470 individuals [with 4058 person-years of follow-up (PYFU)] compared with 3787 (4472 PYFU) and 4467 (10 691 PYFU) in the HIST and CONC cohorts, respectively. The prevalence of non-AIDS-related malignancies prior to baseline tended to be higher in the RAL cohort vs. the HIST cohort [adjusted odds ratio (aOR) 1.31; 95% confidence interval (CI) 0.95–1.80] and vs. the CONC cohort (aOR 1.89; 95% CI 1.37–2.61). In intention-to-treat (ITT) analysis (events: RAL, 50; HIST, 45; CONC, 127), the incidence of all new malignancies was 1.11 (95% CI 0.84–1.46) per 100 PYFU in the RAL cohort vs. 1.20 (95% CI 0.90–1.61) and 0.83 (95% CI 0.70–0.99) in the HIST and CONC cohorts, respectively. After adjustment, there was no evidence for a difference in the risk of malignancies [adjusted rate ratio (RR) 0.73; 95% CI 0.47–1.14 for RALvs. HIST; RR 0.95; 95% CI 0.65–1.39 for RALvs. CONC] or mortality (adjusted RR 0.87; 95% CI 0.53–1.43 for RALvs. HIST; RR 1.14; 95% CI 0.76–1.72 for RALvs. CONC). Conclusions: We found no evidence for an oncogenic risk or poorer survival associated with using RAL compared with control groups.",
keywords = "Raltegravir, observational treatment comparison, propensity scores, risk of cancer, survival",
author = "{the EuroSIDA study group} and A. Cozzi-Lepri and R. Zangerle and L. Machala and K. Zilmer and M. Ristola and C. Pradier and O. Kirk and H. Sambatakou and G. F{\"a}tkenheuer and I. Yust and P. Schmid and M. Gottfredsson and I. Khromova and D. Jilich and R. Flisiak and J. Smidt and B. Rozentale and R. Radoi and Losso, {M. H.} and Lundgren, {J. D.} and A. Mocroft and M. Kundro and B. Schmied and I. Karpov and A. Vassilenko and Mitsura, {V. M.} and D. Paduto and N. Clumeck and {De Wit}, S. and M. Delforge and E. Florence and L. Vandekerckhove and V. Hadziosmanovic and J. Begovac and D. Sedlacek and G. Kronborg and T. Benfield and J. Gerstoft and T. Katzenstein and M{\o}ller, {N. F.} and C. Pedersen and L. Ostergaard and L. Wiese and Nielsen, {L. N.} and I. Aho and Viard, {J. P.} and Girard, {P. M.} and E. Fontas and C. Duvivier and D. Turner",
note = "Publisher Copyright: {\textcopyright} 2017 The Authors. HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association",
year = "2018",
month = feb,
doi = "10.1111/hiv.12557",
language = "אנגלית",
volume = "19",
pages = "102--117",
journal = "HIV Medicine",
issn = "1464-2662",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "2",
}
