Incidence and significance of extensive necrosis found in renal cell carcinoma specimens

Ronan Lev*, Ilan Leibovitch, Jacob Ramon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objectives: Extensive necrosis is a rare finding in primary renal cell carcinoma. Its finding may reflect the biological characteristics of the carcinoma and therefore be of prognostic and clinical value. The purpose of this study was to assess the incidence of necrosis in renal cell carcinoma and its potential prognostic value. Patients and methods: A consecutive retrospective study of 173 patients after radical nephrectomy for renal cell carcinoma was conducted. Clinical and pathological data were collected from hospital medical records and were compiled into a computerized database. Results: Extensive necrosis was found in 31 tumor specimens (17.9%). On univariate analysis, the specimens with extensive necrosis were significantly larger and manifested more perirenal and venous extension than the tumors without necrosis. Size of the renal tumor was the only parameter that remained significant in multivariate analysis (p=0.0001). Overall disease free survival did not differ significantly between patients with necrotic tumors and those without (68% and 66% respectively). Conclusions: The finding of extensive necrosis in renal cell carcinoma does not seem to be related to tumor biology but rather it reflects the relation of size and vascularity of the tumor.

Original languageEnglish
Pages (from-to)138
Number of pages1
JournalBritish Journal of Urology
Issue numberSUPPL. 2
StatePublished - 1997
Externally publishedYes


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