Inactive systemic lupus erythematosus is associated with a normal stimulated TH1/TH2 cytokine secretory pattern

Mirit Amit, Anat Mor, Joshua Weissgarten, Rosalia Rosenberg, Yoram Ramot, Arjeh J. Wysenbeek, Micha J. Rapoport

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives - To determine the Th1/Th2 balance in systemic lupus erythematosus (SLE) patients with inactive disease. Methods - A comprehensive analysis of peak secretion, overall cytokine production and secretory pattern of Th1 and Th2 cytokines from stimulated PBMC of 10 SLE patients with inactive disease and 10 age- and sex-matched controls. Results - No significant differences were found in the peak and total secretion of all cytokines, as well as in the Th1 and Th2 secretory patterns and proliferative response between the two groups. Conclusion - Th1 and Th2 balance in inactive SLE is normal. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)1405-1408
Number of pages4
JournalCytokine
Volume12
Issue number9
DOIs
StatePublished - 2000

Keywords

  • Cytokines
  • Lupus
  • Th
  • Th

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