In vivo 23Na NMR studies of myotonic dystrophy

Tammar Kushnir*, Tatyana Knubovets, Yacov Itzchak, Uzi Eliav, Menachem Sadeh, Lubov Rapoport, Edna Kott, Gil Navon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Myotonic dystrophy is an inherited multi-system disease. Its pathophysiology leading to muscle malfunction and damage is not well understood. 23Na NMR spectroscopy was applied here for an in vivo comparative study of the calf muscles of 7 myotonic dystrophy patients at various stages of the disease and 11 healthy volunteers. Both the total sodium content, expressed as the ratio of the 23Na and 1H water signals, and the fast transverse relaxation time, T(2f), determined from the triple quantum-filtered spectra, increased in correlation with the severity of the disease. The results demonstrate that 23Na NMR enables the quantitation of myotonic dystrophy progression.

Original languageEnglish
Pages (from-to)192-196
Number of pages5
JournalMagnetic Resonance in Medicine
Issue number2
StatePublished - Feb 1997


  • Na NMR
  • myotonic dystrophy
  • triple quantum-filtered spectroscopy


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