TY - JOUR
T1 - In vivo 23Na NMR studies of myotonic dystrophy
AU - Kushnir, Tammar
AU - Knubovets, Tatyana
AU - Itzchak, Yacov
AU - Eliav, Uzi
AU - Sadeh, Menachem
AU - Rapoport, Lubov
AU - Kott, Edna
AU - Navon, Gil
PY - 1997/2
Y1 - 1997/2
N2 - Myotonic dystrophy is an inherited multi-system disease. Its pathophysiology leading to muscle malfunction and damage is not well understood. 23Na NMR spectroscopy was applied here for an in vivo comparative study of the calf muscles of 7 myotonic dystrophy patients at various stages of the disease and 11 healthy volunteers. Both the total sodium content, expressed as the ratio of the 23Na and 1H water signals, and the fast transverse relaxation time, T(2f), determined from the triple quantum-filtered spectra, increased in correlation with the severity of the disease. The results demonstrate that 23Na NMR enables the quantitation of myotonic dystrophy progression.
AB - Myotonic dystrophy is an inherited multi-system disease. Its pathophysiology leading to muscle malfunction and damage is not well understood. 23Na NMR spectroscopy was applied here for an in vivo comparative study of the calf muscles of 7 myotonic dystrophy patients at various stages of the disease and 11 healthy volunteers. Both the total sodium content, expressed as the ratio of the 23Na and 1H water signals, and the fast transverse relaxation time, T(2f), determined from the triple quantum-filtered spectra, increased in correlation with the severity of the disease. The results demonstrate that 23Na NMR enables the quantitation of myotonic dystrophy progression.
KW - Na NMR
KW - myotonic dystrophy
KW - triple quantum-filtered spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=0030614540&partnerID=8YFLogxK
U2 - 10.1002/mrm.1910370209
DO - 10.1002/mrm.1910370209
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AN - SCOPUS:0030614540
SN - 0740-3194
VL - 37
SP - 192
EP - 196
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
IS - 2
ER -