In-vivo simultaneous cortical and intracortical monitoring of cerebral blood flow and mitochondrial redox state in experimental animals

E. Barbiro-Michaely; T. Zuckerman; N. Zarchin; S. Rinkevich; N. Knoller; M. Hadani; A. Mayevsky

doi:10.1117/12.476799

In-vivo simultaneous cortical and intracortical monitoring of cerebral blood flow and mitochondrial redox state in experimental animals

E. Barbiro-Michaely^*, T. Zuckerman, N. Zarchin, S. Rinkevich, N. Knoller, M. Hadani, A. Mayevsky

^*Corresponding author for this work

Research output: Contribution to journal › Conference article › peer-review

Abstract

The responses of the gerbil or rate brain to oxygen deficiency, monitored on the brain surface and in different depths were compared. After the animals were anesthesized, the two common carotid arteries (gerbil) were isolated and prepared for following occlusion. The brain was exposed and two optical probes were located on its surface. Ischemia was induced by occluding the two carotid arteries, and anoxia was performed by inhalation of pure N₂. After recovery, one of the probes was inserted into the braid and a second ischemia or anoxia was performed. The resultant data were analyzed in detail.

Original language	English
Pages (from-to)	22-30
Number of pages	9
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	4955
DOIs	https://doi.org/10.1117/12.476799
State	Published - 2003
Externally published	Yes
Event	PROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Optical Tomography and Spectroscopy of Tissue V - San Jose, CA, United States Duration: 26 Jan 2003 → 29 Jan 2003

Keywords

CBF
Intracranial monitoring
Mitochondrial NADH
Oxidative metabolism

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10.1117/12.476799

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title = "In-vivo simultaneous cortical and intracortical monitoring of cerebral blood flow and mitochondrial redox state in experimental animals",

abstract = "The responses of the gerbil or rate brain to oxygen deficiency, monitored on the brain surface and in different depths were compared. After the animals were anesthesized, the two common carotid arteries (gerbil) were isolated and prepared for following occlusion. The brain was exposed and two optical probes were located on its surface. Ischemia was induced by occluding the two carotid arteries, and anoxia was performed by inhalation of pure N2. After recovery, one of the probes was inserted into the braid and a second ischemia or anoxia was performed. The resultant data were analyzed in detail.",

keywords = "CBF, Intracranial monitoring, Mitochondrial NADH, Oxidative metabolism",

author = "E. Barbiro-Michaely and T. Zuckerman and N. Zarchin and S. Rinkevich and N. Knoller and M. Hadani and A. Mayevsky",

year = "2003",

doi = "10.1117/12.476799",

language = "אנגלית",

volume = "4955",

pages = "22--30",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

issn = "0277-786X",

publisher = "SPIE",

note = "null ; Conference date: 26-01-2003 Through 29-01-2003",

}

Barbiro-Michaely, E, Zuckerman, T, Zarchin, N, Rinkevich, S, Knoller, N, Hadani, M & Mayevsky, A 2003, 'In-vivo simultaneous cortical and intracortical monitoring of cerebral blood flow and mitochondrial redox state in experimental animals', Proceedings of SPIE - The International Society for Optical Engineering, vol. 4955, pp. 22-30. https://doi.org/10.1117/12.476799

In-vivo simultaneous cortical and intracortical monitoring of cerebral blood flow and mitochondrial redox state in experimental animals. / Barbiro-Michaely, E.; Zuckerman, T.; Zarchin, N. et al.

In: Proceedings of SPIE - The International Society for Optical Engineering, Vol. 4955, 2003, p. 22-30.

Research output: Contribution to journal › Conference article › peer-review

TY - JOUR

T1 - In-vivo simultaneous cortical and intracortical monitoring of cerebral blood flow and mitochondrial redox state in experimental animals

AU - Barbiro-Michaely, E.

AU - Zuckerman, T.

AU - Zarchin, N.

AU - Rinkevich, S.

AU - Knoller, N.

AU - Hadani, M.

AU - Mayevsky, A.

PY - 2003

Y1 - 2003

N2 - The responses of the gerbil or rate brain to oxygen deficiency, monitored on the brain surface and in different depths were compared. After the animals were anesthesized, the two common carotid arteries (gerbil) were isolated and prepared for following occlusion. The brain was exposed and two optical probes were located on its surface. Ischemia was induced by occluding the two carotid arteries, and anoxia was performed by inhalation of pure N2. After recovery, one of the probes was inserted into the braid and a second ischemia or anoxia was performed. The resultant data were analyzed in detail.

AB - The responses of the gerbil or rate brain to oxygen deficiency, monitored on the brain surface and in different depths were compared. After the animals were anesthesized, the two common carotid arteries (gerbil) were isolated and prepared for following occlusion. The brain was exposed and two optical probes were located on its surface. Ischemia was induced by occluding the two carotid arteries, and anoxia was performed by inhalation of pure N2. After recovery, one of the probes was inserted into the braid and a second ischemia or anoxia was performed. The resultant data were analyzed in detail.

KW - CBF

KW - Intracranial monitoring

KW - Mitochondrial NADH

KW - Oxidative metabolism

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JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

Y2 - 26 January 2003 through 29 January 2003

ER -

In-vivo simultaneous cortical and intracortical monitoring of cerebral blood flow and mitochondrial redox state in experimental animals

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Keywords

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