In vivo NMR and MRI using injection delivery of laser-polarized xenon

B. M. Goodson; Y. Q. Song; R. E. Taylor; V. D. Schepkin; K. M. Brennan; G. C. Chingas; T. F. Budinger; G. Navon; A. Pines

doi:10.1073/pnas.94.26.14725

In vivo NMR and MRI using injection delivery of laser-polarized xenon

B. M. Goodson
, Y. Q. Song
, R. E. Taylor
, V. D. Schepkin
, K. M. Brennan
, G. C. Chingas
, T. F. Budinger
, G. Navon
, A. Pines^*

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Because xenon NMR is highly sensitive to the local environment, laser- polarized xenon could be a unique probe of living tissues. Realization of clinical and medical science application beyond lung airspace imaging requires methods of efficient delivery of laser-polarized xenon to tissues, because of the short spin-lattice relaxation times and relatively low concentrations of xenon attainable in the body. Preliminary results from the application of a polarized xenon injection technique for in vivo, ¹²⁹Xe NMR/MRI are extrapolated along with a simple model of xenon transit to show that the peak local concentration of polarized xenon delivered to tissues by injection may exceed that delivered by respiration by severalfold.

Original language	English
Pages (from-to)	14725-14729
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	94
Issue number	26
DOIs	https://doi.org/10.1073/pnas.94.26.14725
State	Published - 23 Dec 1997

Keywords

Optical pumping
Xenon injection

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10.1073/pnas.94.26.14725

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abstract = "Because xenon NMR is highly sensitive to the local environment, laser- polarized xenon could be a unique probe of living tissues. Realization of clinical and medical science application beyond lung airspace imaging requires methods of efficient delivery of laser-polarized xenon to tissues, because of the short spin-lattice relaxation times and relatively low concentrations of xenon attainable in the body. Preliminary results from the application of a polarized xenon injection technique for in vivo, 129Xe NMR/MRI are extrapolated along with a simple model of xenon transit to show that the peak local concentration of polarized xenon delivered to tissues by injection may exceed that delivered by respiration by severalfold.",

keywords = "Optical pumping, Xenon injection",

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AU - Goodson, B. M.

AU - Song, Y. Q.

AU - Taylor, R. E.

AU - Schepkin, V. D.

AU - Brennan, K. M.

AU - Chingas, G. C.

AU - Budinger, T. F.

AU - Navon, G.

AU - Pines, A.

PY - 1997/12/23

Y1 - 1997/12/23

N2 - Because xenon NMR is highly sensitive to the local environment, laser- polarized xenon could be a unique probe of living tissues. Realization of clinical and medical science application beyond lung airspace imaging requires methods of efficient delivery of laser-polarized xenon to tissues, because of the short spin-lattice relaxation times and relatively low concentrations of xenon attainable in the body. Preliminary results from the application of a polarized xenon injection technique for in vivo, 129Xe NMR/MRI are extrapolated along with a simple model of xenon transit to show that the peak local concentration of polarized xenon delivered to tissues by injection may exceed that delivered by respiration by severalfold.

AB - Because xenon NMR is highly sensitive to the local environment, laser- polarized xenon could be a unique probe of living tissues. Realization of clinical and medical science application beyond lung airspace imaging requires methods of efficient delivery of laser-polarized xenon to tissues, because of the short spin-lattice relaxation times and relatively low concentrations of xenon attainable in the body. Preliminary results from the application of a polarized xenon injection technique for in vivo, 129Xe NMR/MRI are extrapolated along with a simple model of xenon transit to show that the peak local concentration of polarized xenon delivered to tissues by injection may exceed that delivered by respiration by severalfold.

KW - Optical pumping

KW - Xenon injection

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JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 26

ER -

In vivo NMR and MRI using injection delivery of laser-polarized xenon

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Keywords

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