In vivo NMR and MRI using injection delivery of laser-polarized xenon

B. M. Goodson, Y. Q. Song, R. E. Taylor, V. D. Schepkin, K. M. Brennan, G. C. Chingas, T. F. Budinger, G. Navon, A. Pines

Research output: Contribution to journalArticlepeer-review

Abstract

Because xenon NMR is highly sensitive to the local environment, laser- polarized xenon could be a unique probe of living tissues. Realization of clinical and medical science application beyond lung airspace imaging requires methods of efficient delivery of laser-polarized xenon to tissues, because of the short spin-lattice relaxation times and relatively low concentrations of xenon attainable in the body. Preliminary results from the application of a polarized xenon injection technique for in vivo, 129Xe NMR/MRI are extrapolated along with a simple model of xenon transit to show that the peak local concentration of polarized xenon delivered to tissues by injection may exceed that delivered by respiration by severalfold.

Original languageEnglish
Pages (from-to)14725-14729
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume94
Issue number26
DOIs
StatePublished - 23 Dec 1997

Keywords

  • Optical pumping
  • Xenon injection

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