In vivo laser soldering of incisions in juvenile pig skins, using GaAs or CO2 lasers and a temperature control system

David Simhon*, Marisa Halpern, Tamar Brosh, Tamar Vasilyev, Naam Kariv, Ronit Argaman, Abraham Katzir, Zvi Nevo

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review


Two temperature controlled laser soldering systems were compared, one based on a GaAs laser and the other on a CO2 laser. Both systems were used for bonding full thickness incisions. Methods: 47% bovine serum albumin (BSA) solder was used in the CO2 laser soldering experiments. BSA with 1.8 mg/ml Indocyanine Green (ICG) was used for the GaAs soldering experiments. In both cases the solder was applied onto cuts created in juvenile pig skin and an infrared fiberoptic system was used to monitor and control different temperature and time settings. Differences in tensile strength and wound reparative parameters were compared between GaAs laser, CO2 laser, and Dermabond glued incisions on the seventh day after the operation. Results: The tensile strength of CO2 laser-soldered and Dermabond glued incisions were found to be higher than that of the GaAs laser-soldered incisions. Histological study showed better and faster wound healing characteristics of the CO 2 laser soldered incisions, as compared to the GaAs laser-soldered and glued incisions. Conclusions: Preliminary results of temperature controlled CO2 laser soldered incisions suggest a better wound reparative process over the temperature controlled GaAs laser soldered incisions. Laser soldering offers many advantages over gluing techniques.

Original languageEnglish
Article number32
Pages (from-to)162-175
Number of pages14
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Issue number1
StatePublished - 2004
EventLasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV - San Jose, CA, United States
Duration: 24 Jan 200427 Jan 2004


  • Albumin
  • CO and GaAs lasers
  • Cyanoacrylate; Tensile strength
  • Indocyanine Green
  • Scar morphometric measurements; Histological healing indices
  • Skin incision closure


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