In Vivo Effects of Prostaglandin Analogues Application by Topical Drops or Retrobulbar Injections on the Orbital Fat of a Rat Model

Doha Jbara*, Maya Eiger-Moscovich, Elena Didkovsky, Yariv Keshet, Inbal Avisar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To assess the in vivo effects of bimatoprost 0.03% (Lumigan®) on the orbital fat in a rat model. Methods: Twenty rats were randomly divided into two groups: bimatoprost was administrated to the right eye by topical drops (group 1) or retrobulbar injection (group 2), and saline was administrated to the left eye by similar administration routes (controls). Four weeks later, all rats were sedated and euthanized, both orbits exenterated, and thin sections through the intraconal orbital fat were obtained. Results: Average adipocyte cell count was significantly lower in the bimatoprost treated orbits (drops or retrobulbar injection, 29.5 vs. 67.5 cells per slide in the control globes, p=0.046). Fat cells were not detected in 9/20 (45%) bimatoprost treated orbits     . Conclusions: Orbits treated with bimatoprost by drops or retrobulbar injection demonstrated significant decrease in adipocytes cell count compared with controls. Bimatoprost could be an effective treatment for inactive thyroid eye disease.

Original languageEnglish
Pages (from-to)298-303
Number of pages6
JournalOcular Immunology and Inflammation
Volume31
Issue number2
DOIs
StatePublished - 2023

Funding

FundersFunder number
Claire and Amedee Martier Institute0601248492
Study of Blindness
Visual Disorders
Sackler Faculty of Medicine, Tel-Aviv University

    Keywords

    • Bimatoprost
    • orbital fat atrophy
    • rat model
    • thyroid eye disease

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