@article{60e937806f664dbf8fd7a9a34f48e0e3,
title = "In vivo effect of MPTP on monoamine oxidase activity in mouse striatum",
abstract = "Striatal monoamine oxidase (MAO)-B, but not MAO-A, activity decreased in mice at 2 and 10 days and was back to control values at 20 and 30 days after systemic administration of N-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP). Striatal dopaminergic (DA) depletions were maximal at 2 days and were only partially reversed at 30 days post-treatment. In rats, unilateral kainic acid lesions increased MAO-B but not MAO-A activity probably due to reactive gliosis, but MPTP did not affect DA levels in control and kainic acid-lesioned striata. Findings support the importance of MAO-B in the toxicity of MPTP and suggest that resistance of rat DA neurons to the neurotoxin is probably not due to species differences in MAO-B activity.",
keywords = "N-methyl-4-phenyl-1,2,5,6-tetrahydropyridine toxicity, dopaminergic neuron, kainic acid lesion, monoamine oxidase A, monoamine oxidase B, mouse, rat, striatum",
author = "E. Melamed and Youdim, \{M. B.H.\} and J. Rosenthal and I. Spanier and A. Uzzan and M. Globus",
note = "Funding Information: ment Fund for NeurologicaRl esearchb, y the American Parkinson'sD isease Association and by the Chief Scientist'Bs ureau,the Ministry of Health, Israel.",
year = "1985",
month = dec,
day = "16",
doi = "10.1016/0006-8993(85)91451-9",
language = "אנגלית",
volume = "359",
pages = "360--363",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier BV",
number = "1-2",
}