In vivo effect of MPTP on monoamine oxidase activity in mouse striatum

E. Melamed*, M. B.H. Youdim, J. Rosenthal, I. Spanier, A. Uzzan, M. Globus

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Striatal monoamine oxidase (MAO)-B, but not MAO-A, activity decreased in mice at 2 and 10 days and was back to control values at 20 and 30 days after systemic administration of N-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP). Striatal dopaminergic (DA) depletions were maximal at 2 days and were only partially reversed at 30 days post-treatment. In rats, unilateral kainic acid lesions increased MAO-B but not MAO-A activity probably due to reactive gliosis, but MPTP did not affect DA levels in control and kainic acid-lesioned striata. Findings support the importance of MAO-B in the toxicity of MPTP and suggest that resistance of rat DA neurons to the neurotoxin is probably not due to species differences in MAO-B activity.

Original languageEnglish
Pages (from-to)360-363
Number of pages4
JournalBrain Research
Volume359
Issue number1-2
DOIs
StatePublished - 16 Dec 1985
Externally publishedYes

Funding

FundersFunder number
American Parkinson'sD isease Association
Ministry of Health, State of Israel

    Keywords

    • N-methyl-4-phenyl-1,2,5,6-tetrahydropyridine toxicity
    • dopaminergic neuron
    • kainic acid lesion
    • monoamine oxidase A
    • monoamine oxidase B
    • mouse
    • rat
    • striatum

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