In vivo CAMPATH-1 followed by T cell depleted bone marrow transplantation: A potential new mode of therapy for hepatitis associated severe aplastic anemia (SAA)

A. Nagler, Y. Ilan, G. Varadi, J. Kapelushnik, R. Or

Research output: Contribution to journalArticlepeer-review

Abstract

Bone marrow transplantation (BMT) has been reported as a successful mode of treatment for hepatitis B and associated severe aplastic anemia (SAA). Non-A, non-B, non-C hepatitis is one of the causes of SAA. The etiology of SAA caused by non-A, non-B, non-C hepatitis is unknown. There is evidence that the immune response and, specifically, T cells and monocytes have a major role in both HCV- and HBV-induced liver damage. The liver damage caused by non-A, non-B, non-c hepatitis may be associated with similar mechanisms. We describe an 8-year-old girl who developed SAA post non-A, non-B, non-C hepatitis infection. She was treated by in vivo CAMPATH-1G antibodies followed by T cell depleted HLA-matched BMT and cyclosporin A, resulting in gradual improvement and almost normalization of liver function. We suggest that treatment with CAMPATH-1G followed by T cell-depleted BMT and cyclosporin A could be a novel mode of treatment for viral non-A, non-B, non-C hepatitis-induced liver damage and associated SAA.

Original languageEnglish
Pages (from-to)475-478
Number of pages4
JournalBone Marrow Transplantation
Volume18
Issue number2
StatePublished - Aug 1996
Externally publishedYes

Keywords

  • Allogenic BMT
  • CAMPATH-1G
  • Hepatitis
  • T cell depletion

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