TY - JOUR
T1 - In vitro "wound" healing
T2 - Experimentally based phenomenological modeling
AU - Vermolen, Fred J.
AU - Gefen, Amit
AU - Dunlop, John W.C.
PY - 2012/3
Y1 - 2012/3
N2 - We discuss the applicability of some elementary models for the closure of in vitro "wounds" that are inflicted in monolayer cell cultures (also termed "wound healing assays"). These models can be applied to the simulation of healing of superficial wounds as long as they only concern the epidermis. We test several models that are based on a curvature driven displacement, a simple partial differential equation based model in which the actual cellular density is tracked. Finally, a semi-stochastic cellular based model is evaluated. We discuss several models to simulate the closure of an in vitro wound on a substrate. The formalisms involve a cell-colony model with individual cells, an upscaled model with a cell density, and a phenomenological model where the "wound" edge is tracked by determination of the curvature. The computations give the time-evolution of the "wound" area.
AB - We discuss the applicability of some elementary models for the closure of in vitro "wounds" that are inflicted in monolayer cell cultures (also termed "wound healing assays"). These models can be applied to the simulation of healing of superficial wounds as long as they only concern the epidermis. We test several models that are based on a curvature driven displacement, a simple partial differential equation based model in which the actual cellular density is tracked. Finally, a semi-stochastic cellular based model is evaluated. We discuss several models to simulate the closure of an in vitro wound on a substrate. The formalisms involve a cell-colony model with individual cells, an upscaled model with a cell density, and a phenomenological model where the "wound" edge is tracked by determination of the curvature. The computations give the time-evolution of the "wound" area.
UR - http://www.scopus.com/inward/record.url?scp=84858024987&partnerID=8YFLogxK
U2 - 10.1002/adem.201180080
DO - 10.1002/adem.201180080
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AN - SCOPUS:84858024987
SN - 1438-1656
VL - 14
SP - B76-B88
JO - Advanced Engineering Materials
JF - Advanced Engineering Materials
IS - 3
ER -