TY - JOUR
T1 - In vitro synergy of caspofungin and itraconazole against Aspergillus spp.
T2 - MIC versus minimal effective concentration end points
AU - Shalit, Itamar
AU - Shadkchan, Yona
AU - Samra, Zmira
AU - Osherov, Nir
N1 - Funding Information:
The authors are grateful to Takeda Chemical Industries Ltd., Osaka, Japan, for generously providing the TNP-470. This work was partially supported by grants from Mapfre-Medicine Foundation, FIS 98/1018, and CAM 8.1/11/97.
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Caspofungin and itraconazole were studied alone and in combination against 31 clinical isolates of Aspergillus spp. according to NCCLS M38-P guidelines. MICs and microscopic minimal effective concentrations (MECs) were recorded, and synergy was calculated by using both end points. Synergy or synergy to additivity was found in 30 of 31 isolates by using MIC end points. With MEC end points no synergy was found and indifference was detected in 26 of 31 strains.
AB - Caspofungin and itraconazole were studied alone and in combination against 31 clinical isolates of Aspergillus spp. according to NCCLS M38-P guidelines. MICs and microscopic minimal effective concentrations (MECs) were recorded, and synergy was calculated by using both end points. Synergy or synergy to additivity was found in 30 of 31 isolates by using MIC end points. With MEC end points no synergy was found and indifference was detected in 26 of 31 strains.
UR - http://www.scopus.com/inward/record.url?scp=0037379397&partnerID=8YFLogxK
U2 - 10.1128/AAC.47.4.1416-1418.2003
DO - 10.1128/AAC.47.4.1416-1418.2003
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AN - SCOPUS:0037379397
SN - 0066-4804
VL - 47
SP - 1416
EP - 1418
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 4
ER -