In vitro study of the effect of hyperthermia on normal bladder cell line and on five different transitional cell carcinoma cell lines

H. Matzkin; M. C. Rangel; M. S. Soloway

doi:10.1016/S0022-5347(17)37675-9

In vitro study of the effect of hyperthermia on normal bladder cell line and on five different transitional cell carcinoma cell lines

H. Matzkin, M. C. Rangel, M. S. Soloway^*

^*Corresponding author for this work

University of Miami

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Intraluminal hyperthermia is potentially useful in the management of superficial bladder cancer. The potential inhibitory effect of hyperthermia on various human bladder cancer cell lines, normal human bladder cells and the murine MBT-2 bladder cancer cell line has been studied in vitro. These cell lines were exposed for one hour to 43 ± 0.5C and compared to controls. Cell survival was assessed comparing the cell growth curve and colony formation. The human transitional cell carcinoma (TCC) cell lines vary in their sensitivity to heat. MGH-U1 was the most heat sensitive cell line. The human A-1698, CUB-2, UM-UC-3 and the murine MBT-2 lines were heat insensitive. We conclude that the cytocidal effect of hyperthermia in bladder transitional cell carcinoma is variable. Further experiments using the combination of hyperthermia and intravesical anticancer agents are in progress.

Original language	English
Pages (from-to)	1671-1674
Number of pages	4
Journal	Journal of Urology
Volume	147
Issue number	6
DOIs	https://doi.org/10.1016/S0022-5347(17)37675-9
State	Published - 1992
Externally published	Yes

Keywords

bladder neoplasms
chemotherapy
hyperthermia

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0022-5347(17)37675-9

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title = "In vitro study of the effect of hyperthermia on normal bladder cell line and on five different transitional cell carcinoma cell lines",

abstract = "Intraluminal hyperthermia is potentially useful in the management of superficial bladder cancer. The potential inhibitory effect of hyperthermia on various human bladder cancer cell lines, normal human bladder cells and the murine MBT-2 bladder cancer cell line has been studied in vitro. These cell lines were exposed for one hour to 43 ± 0.5C and compared to controls. Cell survival was assessed comparing the cell growth curve and colony formation. The human transitional cell carcinoma (TCC) cell lines vary in their sensitivity to heat. MGH-U1 was the most heat sensitive cell line. The human A-1698, CUB-2, UM-UC-3 and the murine MBT-2 lines were heat insensitive. We conclude that the cytocidal effect of hyperthermia in bladder transitional cell carcinoma is variable. Further experiments using the combination of hyperthermia and intravesical anticancer agents are in progress.",

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AU - Rangel, M. C.

AU - Soloway, M. S.

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Y1 - 1992

N2 - Intraluminal hyperthermia is potentially useful in the management of superficial bladder cancer. The potential inhibitory effect of hyperthermia on various human bladder cancer cell lines, normal human bladder cells and the murine MBT-2 bladder cancer cell line has been studied in vitro. These cell lines were exposed for one hour to 43 ± 0.5C and compared to controls. Cell survival was assessed comparing the cell growth curve and colony formation. The human transitional cell carcinoma (TCC) cell lines vary in their sensitivity to heat. MGH-U1 was the most heat sensitive cell line. The human A-1698, CUB-2, UM-UC-3 and the murine MBT-2 lines were heat insensitive. We conclude that the cytocidal effect of hyperthermia in bladder transitional cell carcinoma is variable. Further experiments using the combination of hyperthermia and intravesical anticancer agents are in progress.

AB - Intraluminal hyperthermia is potentially useful in the management of superficial bladder cancer. The potential inhibitory effect of hyperthermia on various human bladder cancer cell lines, normal human bladder cells and the murine MBT-2 bladder cancer cell line has been studied in vitro. These cell lines were exposed for one hour to 43 ± 0.5C and compared to controls. Cell survival was assessed comparing the cell growth curve and colony formation. The human transitional cell carcinoma (TCC) cell lines vary in their sensitivity to heat. MGH-U1 was the most heat sensitive cell line. The human A-1698, CUB-2, UM-UC-3 and the murine MBT-2 lines were heat insensitive. We conclude that the cytocidal effect of hyperthermia in bladder transitional cell carcinoma is variable. Further experiments using the combination of hyperthermia and intravesical anticancer agents are in progress.

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In vitro study of the effect of hyperthermia on normal bladder cell line and on five different transitional cell carcinoma cell lines

Abstract

Keywords

UN SDGs

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