In vitro proliferative advantage of bone marrow cells with tetrasomy 8 in Ewing sarcoma

Luba Trakhtenbrot; Yoram Neumann; Matilda Mandel; Amos Toren; Nelly Gipsh; Esther Rosner; Gideon Rechavi; Frida Brok-Simoni

doi:10.1016/S0165-4608(96)00090-8

In vitro proliferative advantage of bone marrow cells with tetrasomy 8 in Ewing sarcoma

Luba Trakhtenbrot^*, Yoram Neumann, Matilda Mandel, Amos Toren, Nelly Gipsh, Esther Rosner, Gideon Rechavi, Frida Brok-Simoni

^*Corresponding author for this work

Hematology

Sheba Medical Center at Tel Hashomer

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We describe a case of a 14.5-year-old boy with a clinically aggressive pelvic Ewing sarcoma. The tumor cells showed the presence of a typical t(11;22)(q24;q12) aberration and gains of chromosomes 8, 10, 14, and 21. To determine the size of the trisomy and tetrasomy 8 clones an interphase analysis by fluorescence in situ hybridization with a centromere-specific chromosome 8 probe was performed. Significant quantitative differences between metaphase and interphase data were obtained. It was shown that culturing of bone marrow cells leads to enrichment of tetrasomy 8 population that may be explained by the proliferative advantage of the tetrasomy 8 cells.

Original language	English
Pages (from-to)	176-178
Number of pages	3
Journal	Cancer Genetics and Cytogenetics
Volume	90
Issue number	2
DOIs	https://doi.org/10.1016/S0165-4608(96)00090-8
State	Published - Sep 1996

Funding

Funders	Funder number
Israel Cancer Research Fund

UN SDGs

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10.1016/S0165-4608(96)00090-8

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title = "In vitro proliferative advantage of bone marrow cells with tetrasomy 8 in Ewing sarcoma",

abstract = "We describe a case of a 14.5-year-old boy with a clinically aggressive pelvic Ewing sarcoma. The tumor cells showed the presence of a typical t(11;22)(q24;q12) aberration and gains of chromosomes 8, 10, 14, and 21. To determine the size of the trisomy and tetrasomy 8 clones an interphase analysis by fluorescence in situ hybridization with a centromere-specific chromosome 8 probe was performed. Significant quantitative differences between metaphase and interphase data were obtained. It was shown that culturing of bone marrow cells leads to enrichment of tetrasomy 8 population that may be explained by the proliferative advantage of the tetrasomy 8 cells.",

author = "Luba Trakhtenbrot and Yoram Neumann and Matilda Mandel and Amos Toren and Nelly Gipsh and Esther Rosner and Gideon Rechavi and Frida Brok-Simoni",

note = "Funding Information: The authors thank Sara Barman for excellent technical assistance. This work was supported in part by the Israel Cancer Research Fund.",

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AU - Trakhtenbrot, Luba

AU - Neumann, Yoram

AU - Mandel, Matilda

AU - Toren, Amos

AU - Gipsh, Nelly

AU - Rosner, Esther

AU - Rechavi, Gideon

AU - Brok-Simoni, Frida

N1 - Funding Information: The authors thank Sara Barman for excellent technical assistance. This work was supported in part by the Israel Cancer Research Fund.

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N2 - We describe a case of a 14.5-year-old boy with a clinically aggressive pelvic Ewing sarcoma. The tumor cells showed the presence of a typical t(11;22)(q24;q12) aberration and gains of chromosomes 8, 10, 14, and 21. To determine the size of the trisomy and tetrasomy 8 clones an interphase analysis by fluorescence in situ hybridization with a centromere-specific chromosome 8 probe was performed. Significant quantitative differences between metaphase and interphase data were obtained. It was shown that culturing of bone marrow cells leads to enrichment of tetrasomy 8 population that may be explained by the proliferative advantage of the tetrasomy 8 cells.

AB - We describe a case of a 14.5-year-old boy with a clinically aggressive pelvic Ewing sarcoma. The tumor cells showed the presence of a typical t(11;22)(q24;q12) aberration and gains of chromosomes 8, 10, 14, and 21. To determine the size of the trisomy and tetrasomy 8 clones an interphase analysis by fluorescence in situ hybridization with a centromere-specific chromosome 8 probe was performed. Significant quantitative differences between metaphase and interphase data were obtained. It was shown that culturing of bone marrow cells leads to enrichment of tetrasomy 8 population that may be explained by the proliferative advantage of the tetrasomy 8 cells.

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In vitro proliferative advantage of bone marrow cells with tetrasomy 8 in Ewing sarcoma

Abstract

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UN SDGs

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