In vitro fertilization and oocyte donation in women 45 years of age and older

Y. Yaron, A. Amit, S. M. Brenner, M. R. Peyser, M. P. David, J. B. Lessing*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To assess the reproductive potential in women ≥ 45 years of age. Design: Retrospective analysis. Setting: In vitro fertilization-embryo transfer unit, standard IVF and oocyte donation programs. Patients: One hundred twenty-seven patients ≥ 45 years old who applied for treatment of infertility. Intervention: Thirty-one patients underwent 52 treatment cycles in standard IVF. Ninety-six patients underwent 220 oocyte donation cycles. Results: Of the 52 standard IVF cycles, oocytes were retrieved successfully in only 32. Of these, fertilization and ET were performed in 21 cycles. None of these treatment cycles resulted in a clinical pregnancy. Of the 220 oocyte donation cycles, fertilization and ET were accomplished in 189 cycles. These resulted in 33 (17.5% per transfer) clinical pregnancies. Conclusions: These results suggest that oocyte donation may extend the reproductive potential in women ≥ 45 years old when little hope is offered by standard IVF.

Original languageEnglish
Pages (from-to)71-76
Number of pages6
JournalFertility and Sterility
Volume63
Issue number1
DOIs
StatePublished - 1995
Externally publishedYes

Keywords

  • IVF
  • aging
  • endometrial receptivity
  • oocyte donation

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