@article{05d6206d555e4adbbe969e44b2300bee,
title = "In vitro effects of insulin on aldosterone production in rat zona glomerulosa cells",
abstract = "Though long standing diabetes mellitus is frequently accompanied by hypoaldosteronism, the role of insulin in this setting has never been clearly established. In the present study we have examined the direct effects of insulin on aldosterone production in rat zona glomerulosa cells in vitro. Insulin is shown to directly stimulate aldosterone production in a dose dependent manner, and to attenuate angiotensin II mediated aldosterone production, without affecting angiotensin II receptor binding kinetics. Insulin had no effect on aldosterone production mediated by the other physiological stimuli (K+ and ACTH). These data suggest a possible interaction between insulin and angiotensin II in the regulation of aldosterone secretion.",
author = "Dan Petrasek and Gerard Jensen and Michael Tuck and Naftali Stern",
note = "Funding Information: Acknowledgements This work was supported by a Veterans Administration M.R.I.S. grant. The authors wish to thank Stephen Jensen for helpful discussions. The authors also wish to thank Andrew Tuck for his expert word processing assistance in preparation of this manuscript.",
year = "1992",
doi = "10.1016/0024-3205(92)90062-T",
language = "אנגלית",
volume = "50",
pages = "1781--1787",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "23",
}
