In vitro effect of statins on cytokine production and mitogen response of human peripheral blood mononuclear cells

Hanna Bessler, Hertzel Salman, Michael Bergman, Rachel Straussberg, Meir Djaldetti

Research output: Contribution to journalArticlepeer-review

Abstract

The in vitro effect of the hydrophilic statin - pravastatin - and three hydrophobic statins - atorvastatin, lovastatin and simvastatin - on the production of IL-1β, IL-1ra, IL-2, IL-6 and IFN-γ by human peripheral blood mononuclear cells (PBMC) and their response to mitogens was examined. Lovastatin and simvastatin increased the production of IL-1β in a dose dependent manner and reduced secretion of IL-1ra at high concentration. These two statins exerted a dose dependent inhibitory effect on IL-2 production and reduced the secretion of IFNγ at high dose. Atorvastatin did not affect IL-1β, but suppressed IL-1ra, IL-2 and IFNγ production. Atorvastatin, lovastatin and simvastatin caused a dose dependent inhibition of mitogen-induced proliferation of PBMC. IL-6 production was not affected by any one of the statins. While pravastatin caused a slight reduction in the proliferative response of PBMC to PHA, it did not affect either their response to Con A and PWM, or the secretion of cytokines tested.

Original languageEnglish
Pages (from-to)73-77
Number of pages5
JournalClinical Immunology
Volume117
Issue number1
DOIs
StatePublished - Oct 2005

Keywords

  • Atorvastatin
  • Interleukins
  • Lovastatin
  • Mitogen response
  • Mononuclear cells
  • Pravastatin
  • Simvastatin

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