In vitro cytokine production in patients with iron deficiency anemia

Michael Bergman; Hanna Bessler; Hertzel Salman; Dimitri Siomin; Rachel Straussberg; Meir Djaldetti

doi:10.1016/j.clim.2004.08.011

In vitro cytokine production in patients with iron deficiency anemia

Michael Bergman, Hanna Bessler, Hertzel Salman, Dimitri Siomin, Rachel Straussberg, Meir Djaldetti

Research output: Contribution to journal › Article › peer-review

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Abstract

The in vitro production of interleukin (IL)-1β, IL-2, IL-6, IL-10, and tumor necrosis factor alpha (TNFα) by peripheral blood mononuclear cells (PBMC) from 20 patients with iron deficiency anemia (IDA) was examined before and after iron supplementation and compared to values obtained for PBMC from healthy controls. A significant decrease in IL-2 production was observed in IDA patients, whereas the secretion of the other cytokines did not differ from that of controls. Addition of iron to the culture medium did not affect the secretion of IL-2 and IL-1β, but caused an increase in IL-6, IL-10, and TNF-α production. Since a deficiency in IL-2 production plays a role in the pathogenesis of certain infectious and malignant diseases, the results of the present study may explain in part the increased susceptibility to infections observed in patients with IDA.

Original language	English
Pages (from-to)	340-344
Number of pages	5
Journal	Clinical Immunology
Volume	113
Issue number	3
DOIs	https://doi.org/10.1016/j.clim.2004.08.011
State	Published - Dec 2004
Externally published	Yes

Keywords

Cytokines
Infections
Iron
Iron deficiency anemia

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10.1016/j.clim.2004.08.011

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title = "In vitro cytokine production in patients with iron deficiency anemia",

abstract = "The in vitro production of interleukin (IL)-1β, IL-2, IL-6, IL-10, and tumor necrosis factor alpha (TNFα) by peripheral blood mononuclear cells (PBMC) from 20 patients with iron deficiency anemia (IDA) was examined before and after iron supplementation and compared to values obtained for PBMC from healthy controls. A significant decrease in IL-2 production was observed in IDA patients, whereas the secretion of the other cytokines did not differ from that of controls. Addition of iron to the culture medium did not affect the secretion of IL-2 and IL-1β, but caused an increase in IL-6, IL-10, and TNF-α production. Since a deficiency in IL-2 production plays a role in the pathogenesis of certain infectious and malignant diseases, the results of the present study may explain in part the increased susceptibility to infections observed in patients with IDA.",

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author = "Michael Bergman and Hanna Bessler and Hertzel Salman and Dimitri Siomin and Rachel Straussberg and Meir Djaldetti",

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AU - Bergman, Michael

AU - Bessler, Hanna

AU - Salman, Hertzel

AU - Siomin, Dimitri

AU - Straussberg, Rachel

AU - Djaldetti, Meir

PY - 2004/12

Y1 - 2004/12

N2 - The in vitro production of interleukin (IL)-1β, IL-2, IL-6, IL-10, and tumor necrosis factor alpha (TNFα) by peripheral blood mononuclear cells (PBMC) from 20 patients with iron deficiency anemia (IDA) was examined before and after iron supplementation and compared to values obtained for PBMC from healthy controls. A significant decrease in IL-2 production was observed in IDA patients, whereas the secretion of the other cytokines did not differ from that of controls. Addition of iron to the culture medium did not affect the secretion of IL-2 and IL-1β, but caused an increase in IL-6, IL-10, and TNF-α production. Since a deficiency in IL-2 production plays a role in the pathogenesis of certain infectious and malignant diseases, the results of the present study may explain in part the increased susceptibility to infections observed in patients with IDA.

AB - The in vitro production of interleukin (IL)-1β, IL-2, IL-6, IL-10, and tumor necrosis factor alpha (TNFα) by peripheral blood mononuclear cells (PBMC) from 20 patients with iron deficiency anemia (IDA) was examined before and after iron supplementation and compared to values obtained for PBMC from healthy controls. A significant decrease in IL-2 production was observed in IDA patients, whereas the secretion of the other cytokines did not differ from that of controls. Addition of iron to the culture medium did not affect the secretion of IL-2 and IL-1β, but caused an increase in IL-6, IL-10, and TNF-α production. Since a deficiency in IL-2 production plays a role in the pathogenesis of certain infectious and malignant diseases, the results of the present study may explain in part the increased susceptibility to infections observed in patients with IDA.

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KW - Infections

KW - Iron

KW - Iron deficiency anemia

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In vitro cytokine production in patients with iron deficiency anemia

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Keywords

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