In vitro characterization of MOD-5014, a novel long-acting carboxy-terminal peptide (CTP)-modified activated FVII

Keyphrases

• Carboxyl Terminus 100%
• In Vitro Characterization 100%
• Peptide-modified 100%
• Recombinant FVIIa 100%
• Hemophilia 66%
• Thrombin Generation 66%
• Stimulatory Effect 33%
• Effective Treatment 33%
• In Vitro Pharmacology 33%
• Low Affinity 33%
• Bleeding 33%
• Dose Effect 33%
• Subcutaneous Injection 33%
• Specific Activity 33%
• Proteolytic Activity 33%
• Incubation 33%
• Deactivation 33%
• Commercially Available 33%
• Clinical Setting 33%
• Heparin 33%
• Antithrombin 33%
• Platelets 33%
• Intravenous Injection 33%
• In Vitro Activity 33%
• Surface Plasmon Resonance 33%
• Prophylactic Use 33%
• Protein Substrate 33%
• Short Half-life 33%
• Comprehensive Evaluation 33%
• Platelet Membrane 33%
• Tissue Factor 33%
• Synthetic Substrate 33%
• Hemostatic Effect 33%
• Activated Platelets 33%
• Clot Formation 33%
• On-demand Treatment 33%
• Tissue Factor Pathway inhibitor-2 (TFPI-2) 33%
• Rotational Thromboelastometry (ROTEM) 33%
• Clotting Activity 33%
• FVIIa 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Thrombin 100%
• Haemophilia 100%
• Subcutaneous Injection 50%
• Bleeding 50%
• Clinical Study 50%
• Heparin 50%
• Surface Plasmon Resonance 50%
• Thromboplastin 50%
• Hemostatic Agent 50%
• Antithrombin 50%
• Tissue Factor Pathway Inhibitor 50%