In vitro antibacterial efficacy of a new chlorhexidine slow-release device

Shaul Lin*, Liran Levin, Ervin I. Weiss, Micha Peled, Zvi Fuss

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: The aim of this study was to evaluate and compare the antibacterial effect of chlorhexidine and calcium hydroxide slow-release devices on oral bacteria. Method and Materials: The agar diffusion test was used to evaluate the antibacterial effect of the slow-release devices Activ Point (chlorhexidine; Roeko) and Calcium Hydroxide Plus Point (Roeko) on 8 anaerobic and 2 facultative oral bacterial strains, as well as 2 bacterial cultures randomly sampled from necrotic root canals and incubated in anaerobic and aerobic broth for 48 hours. The efficiency of the medicaments against the various strains was evaluated using a nonparametric test (Friedman type) and a second nonparametric test (Wilcoxon's signed rank test). Results: Activ Point produced significantly larger inhibition zones (P < .001) than the calcium hydroxide slow-release device around all tested bacterial strains. Conclusion: The chlorhexidine slow-release device (Activ Point) exhibited significant antibacterial activity in the agar diffusion test and merits study as an intracanal medicament.

Original languageEnglish
Pages (from-to)391-394
Number of pages4
JournalQuintessence International
Issue number5
StatePublished - May 2006
Externally publishedYes


  • Agar diffusion test
  • Calcium hydroxide
  • Chlorhexidine
  • Slow-release device


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