In-thrombus thrombin secretion: a new diagnostic marker of atrial fibrillation in cryptogenic stroke

Ze'ev Itsekson Hayosh; Eiman Abu Bandora; Natalia Shelestovich; Maya Nulman; Mati Bakon; Gal Yaniv; Boris Khaitovitch; Shmuel Balan; Alexandra Gerasimova; Tali Drori; Stefan Mausbach; Yvonne Schwammenthal; Arnon Afek; Joab Chapman; Efrat Shavit Stein; David Orion

In-thrombus thrombin secretion: a new diagnostic marker of atrial fibrillation in cryptogenic stroke

Ze'ev Itsekson Hayosh, Eiman Abu Bandora, Natalia Shelestovich, Maya Nulman, Mati Bakon, Gal Yaniv, Boris Khaitovitch, Shmuel Balan, Alexandra Gerasimova, Tali Drori, Stefan Mausbach, Yvonne Schwammenthal, Arnon Afek, Joab Chapman, Efrat Shavit Stein, David Orion

Neurology

Research output: Contribution to journal › Article › peer-review

Abstract

Endovascularly retrieved clots may be a potential resource for diagnosing stroke etiology. This method may influence secondary prevention treatment. We measure thrombin activity eluted by serially washing clots. We concluded that an assay measuring the change in thrombin in clots retrieved during acute stroke endovascular thrombectomy procedures may serve as a diagnostic marker of the origin of the clot. The suggested mechanism for these differences may be the clot location before its retrieval, with high blood flow causing thrombin washout in atherosclerotic clots, in contrast to atrium appendage low blood flow retaining high thrombin levels.

Original language	English
Pages (from-to)	853-854
Number of pages	2
Journal	Israel Medical Association Journal
Volume	25
Issue number	12
State	Published - 1 Dec 2022

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Itsekson Hayosh, Z., Abu Bandora, E., Shelestovich, N., Nulman, M., Bakon, M., Yaniv, G., Khaitovitch, B., Balan, S., Gerasimova, A., Drori, T., Mausbach, S., Schwammenthal, Y., Afek, A., Chapman, J., Shavit Stein, E., & Orion, D. (2022). In-thrombus thrombin secretion: a new diagnostic marker of atrial fibrillation in cryptogenic stroke. Israel Medical Association Journal, 25(12), 853-854.

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title = "In-thrombus thrombin secretion: a new diagnostic marker of atrial fibrillation in cryptogenic stroke",

abstract = "Endovascularly retrieved clots may be a potential resource for diagnosing stroke etiology. This method may influence secondary prevention treatment. We measure thrombin activity eluted by serially washing clots. We concluded that an assay measuring the change in thrombin in clots retrieved during acute stroke endovascular thrombectomy procedures may serve as a diagnostic marker of the origin of the clot. The suggested mechanism for these differences may be the clot location before its retrieval, with high blood flow causing thrombin washout in atherosclerotic clots, in contrast to atrium appendage low blood flow retaining high thrombin levels.",

author = "{Itsekson Hayosh}, Ze'ev and {Abu Bandora}, Eiman and Natalia Shelestovich and Maya Nulman and Mati Bakon and Gal Yaniv and Boris Khaitovitch and Shmuel Balan and Alexandra Gerasimova and Tali Drori and Stefan Mausbach and Yvonne Schwammenthal and Arnon Afek and Joab Chapman and {Shavit Stein}, Efrat and David Orion",

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Itsekson Hayosh, Z, Abu Bandora, E, Shelestovich, N, Nulman, M, Bakon, M, Yaniv, G, Khaitovitch, B, Balan, S, Gerasimova, A, Drori, T, Mausbach, S, Schwammenthal, Y , Afek, A , Chapman, J , Shavit Stein, E & Orion, D 2022, 'In-thrombus thrombin secretion: a new diagnostic marker of atrial fibrillation in cryptogenic stroke', Israel Medical Association Journal, vol. 25, no. 12, pp. 853-854.

TY - JOUR

T1 - In-thrombus thrombin secretion

T2 - a new diagnostic marker of atrial fibrillation in cryptogenic stroke

AU - Itsekson Hayosh, Ze'ev

AU - Abu Bandora, Eiman

AU - Shelestovich, Natalia

AU - Nulman, Maya

AU - Bakon, Mati

AU - Yaniv, Gal

AU - Khaitovitch, Boris

AU - Balan, Shmuel

AU - Gerasimova, Alexandra

AU - Drori, Tali

AU - Mausbach, Stefan

AU - Schwammenthal, Yvonne

AU - Afek, Arnon

AU - Chapman, Joab

AU - Shavit Stein, Efrat

AU - Orion, David

PY - 2022/12/1

Y1 - 2022/12/1

N2 - Endovascularly retrieved clots may be a potential resource for diagnosing stroke etiology. This method may influence secondary prevention treatment. We measure thrombin activity eluted by serially washing clots. We concluded that an assay measuring the change in thrombin in clots retrieved during acute stroke endovascular thrombectomy procedures may serve as a diagnostic marker of the origin of the clot. The suggested mechanism for these differences may be the clot location before its retrieval, with high blood flow causing thrombin washout in atherosclerotic clots, in contrast to atrium appendage low blood flow retaining high thrombin levels.

AB - Endovascularly retrieved clots may be a potential resource for diagnosing stroke etiology. This method may influence secondary prevention treatment. We measure thrombin activity eluted by serially washing clots. We concluded that an assay measuring the change in thrombin in clots retrieved during acute stroke endovascular thrombectomy procedures may serve as a diagnostic marker of the origin of the clot. The suggested mechanism for these differences may be the clot location before its retrieval, with high blood flow causing thrombin washout in atherosclerotic clots, in contrast to atrium appendage low blood flow retaining high thrombin levels.

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C2 - 37584409

AN - SCOPUS:85168068575

SN - 1565-1088

VL - 25

SP - 853

EP - 854

JO - Israel Medical Association Journal

JF - Israel Medical Association Journal

IS - 12

ER -

In-thrombus thrombin secretion: a new diagnostic marker of atrial fibrillation in cryptogenic stroke

Abstract

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