In situ ablation of solid tumors by electric forces and its effect on the tumor microenvironment and anti-tumor immunity

Yona Keisari*, Rafi Korenstein

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Several electric-based cancer treatments were developed for in situ ablation of solid tumors. The electrical parameters used for treatment range from several volts per cm delivered for a long time period, to high electric fields (300-3000 V/cm) and very high electric fields (up to 300 kV/cm, 3-300 ns pulse duration). The treatment can be delivered as a continuous treatment or pulses. These treatments are either based on electrostimulation alone or in conjunction with chemotherapeutic drugs. In this chapter, we summarized data on the effect of various types of electric ablation of cancer in various metastatic tumors in mice and in clinical trials. We discuss the role of electric ablation in changes that occur in the tumor microenvironment, infiltration of immune cells into the tumor, and induction of antitumor immunity. Special focus is given to the role of these responses in the elimination of residual metastatic cells, and the possible enforcement of such antitumor reactions by various immunostimulators.

Original languageEnglish
Title of host publicationTumor Ablation
Subtitle of host publicationEffects on Systemic and Local Anti-Tumor Immunity and on Other Tumor-Microenvironment Interactions
PublisherSpringer Netherlands
Number of pages21
ISBN (Electronic)9789400746947
ISBN (Print)9789400746930
StatePublished - 1 Jan 2013


  • Antimetastatic
  • Antitumor immunity
  • Direct current
  • Electric ablation
  • Electric currents
  • Electric fields
  • Electrochemical
  • Electrochemotherapy
  • Electrodes
  • Electrolytic ablation
  • Electromagnetic radiation
  • Electropermeabilization
  • Electroporation
  • Electrotherapy
  • Experimental tumors
  • High electric fields
  • High frequency
  • Human tumors
  • Immunostimulation
  • Low electric fields
  • Low frequency
  • Low intensity
  • Metastatic tumors
  • Millimetric wave
  • Pulsed electric currents


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