In search of critical dsRNA targets of ADAR1

Erez Y. Levanon*, Roni Cohen-Fultheim, Eli Eisenberg

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Recent studies have underscored the pivotal role of adenosine-to-inosine RNA editing, catalyzed by ADAR1, in suppressing innate immune interferon responses triggered by cellular double-stranded RNA (dsRNA). However, the specific ADAR1 editing targets crucial for this regulatory function remain elusive. We review analyses of transcriptome-wide ADAR1 editing patterns and their evolutionary dynamics, which offer valuable insights into this unresolved query. The growing appreciation of the significance of immunogenic dsRNAs and their editing in inflammatory and autoimmune diseases and cancer calls for a more comprehensive understanding of dsRNA immunogenicity, which may promote our understanding of these diseases and open doors to therapeutic avenues.

Original languageEnglish
Pages (from-to)250-259
Number of pages10
JournalTrends in Genetics
Volume40
Issue number3
DOIs
StatePublished - Mar 2024

Funding

FundersFunder number
European Commission
Israel Science Foundation1945/18, 2637/23

    Keywords

    • ADAR
    • MDA5
    • RNA editing
    • double-stranded RNA
    • innate immunity

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