Improvement in survival during the past 4 decades among patients with anterior skull base cancer

Ziv Gil, Dan M. Fliss, Oren Cavel, Jatin P. Shah, Dennis H. Kraus

Research output: Contribution to journalArticlepeer-review

Abstract

Background The aims of this study were to determine the trends in survival of patients with anterior skull base cancer over several decades and to identify time-related changes in the demographic and clinical characteristics of this population. Methods In all, 282 patients who underwent craniofacial resection at Memorial Sloan-Kettering Cancer Center and Tel Aviv Medical Center were studied. Patients were categorized in accord with the period of surgery: early (1973-1984, n = 34), intermediate (1985-1996, n = 72), and later (1997-2008, n = 176). Results Patients operated after 1996 had higher rates of comorbidity, dural and pterygopalatine invasion, and multicompartmental involvement than those operated before 1996 (p ≤.001). There was a significant improvement in 5-year overall and disease-specific survival, from 55% and 57%, respectively, for patients operated before 1996, to 66% and 70%, respectively, for those operated after 1996 (p =.02 and p =.006, respectively). On multivariate analysis, surgery after 1996 was an independent predictor of outcome (HR, 0.39, p <.001). Conclusions The survival of patients with anterior skull base cancer is improving. Surgery after 1996 is an independent prognostic factor for an improved outcome.

Original languageEnglish
Pages (from-to)1212-1217
Number of pages6
JournalHead and Neck
Volume34
Issue number9
DOIs
StatePublished - Sep 2012
Externally publishedYes

Keywords

  • craniofacial resection
  • nasal cavity
  • sinuses
  • skull base
  • squamous cell carcinoma
  • subcranial
  • survival

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