TY - JOUR
T1 - Improved outcome in childhood B-cell lymphoma with the intensified French LMB protocol
AU - Yaniv, Isaac
AU - Fischer, Salvador
AU - Mor, Celia
AU - Stark, Batia
AU - Goshen, Yaacov
AU - Stein, Jeremiah
AU - Cohen, Ian J.
AU - Zaizov, Rina
N1 - Funding Information:
Contributions to this work by J. Goltman and S. S. Mitra of the University of Rhode Island, and C. T. Moynihan of Rensselaer Polytechnic Institute, are gratefully acknowledged.
PY - 2000/7
Y1 - 2000/7
N2 - Background. During the last 20 years, 120 children with B cell lymphoma were treated at the National Pediatric Hematology/Oncology Center of Israel. Until 1986, 63 patients received an institutional protocol (BMC), and thereafter 57 patients received a modified French LMB protocol. We report the results of a retrospective analysis comparing the results of these two protocols. Procedure. Patient characteristics were similar in both groups except for stage of disease and lactate dehydrogenase (LDH) levels. Significantly more patients in the LMB group had higher stage disease, and the LDH levels also were higher (<600 μg/ml). Results. Fifty-four of fifty- seven children on the modified LMB protocol are alive, disease-free, with an overall event-free survival of 94% (median follow-up of 73 months). Event- free survival for stages I, II, and III patients is 100%, and for stage IV 77%, whereas the overall event-free survival was 58% among 63 children treated previously, and for stage IV patients only 10%. Severe marrow suppression and neutropenic enterocolitis were the major complications of this intensive protocol. Conclusions. Intensive chemotherapy with a modified LMB protocol and modern supportive care result in a high cure rate of childhood B cell lymphoma even in patients with advanced disease. Med. Pediatr. (C) 2000 Wiley-Liss, Inc.
AB - Background. During the last 20 years, 120 children with B cell lymphoma were treated at the National Pediatric Hematology/Oncology Center of Israel. Until 1986, 63 patients received an institutional protocol (BMC), and thereafter 57 patients received a modified French LMB protocol. We report the results of a retrospective analysis comparing the results of these two protocols. Procedure. Patient characteristics were similar in both groups except for stage of disease and lactate dehydrogenase (LDH) levels. Significantly more patients in the LMB group had higher stage disease, and the LDH levels also were higher (<600 μg/ml). Results. Fifty-four of fifty- seven children on the modified LMB protocol are alive, disease-free, with an overall event-free survival of 94% (median follow-up of 73 months). Event- free survival for stages I, II, and III patients is 100%, and for stage IV 77%, whereas the overall event-free survival was 58% among 63 children treated previously, and for stage IV patients only 10%. Severe marrow suppression and neutropenic enterocolitis were the major complications of this intensive protocol. Conclusions. Intensive chemotherapy with a modified LMB protocol and modern supportive care result in a high cure rate of childhood B cell lymphoma even in patients with advanced disease. Med. Pediatr. (C) 2000 Wiley-Liss, Inc.
KW - Burkitt lymphoma
KW - Chemotherapy
KW - Childhood lymphoma
KW - LMB protocol
UR - http://www.scopus.com/inward/record.url?scp=0033933848&partnerID=8YFLogxK
U2 - 10.1002/1096-911X(200007)35:1<8::AID-MPO2>3.0.CO;2-P
DO - 10.1002/1096-911X(200007)35:1<8::AID-MPO2>3.0.CO;2-P
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AN - SCOPUS:0033933848
SN - 1545-5009
VL - 35
SP - 8
EP - 12
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
IS - 1
ER -
