TY - JOUR
T1 - Improved antimicrobial peptides based on acyl-lysine oligomers
AU - Radzishevsky, Inna S.
AU - Rotem, Shahar
AU - Bourdetsky, Dmitry
AU - Navon-Venezia, Shiri
AU - Carmeli, Yehuda
AU - Mor, Amram
N1 - Funding Information:
This work was supported by The Israel Science Foundation (grant no. 387/03) and by BiolineRx (grant no. 2006992).
PY - 2007/6
Y1 - 2007/6
N2 - We describe peptidomimetic oligomers that show rapid, nonhemolytic, broad-spectrum bactericidal properties in mice and do not induce the emergence of resistance. The oligomers contain acyl chains, which prevent the formation of stable secondary structure. This design appears advantageous over conventional antimicrobial peptides with respect to in vivo efficacy and safety, and may provide a convenient platform for the development of peptide antibiotics.
AB - We describe peptidomimetic oligomers that show rapid, nonhemolytic, broad-spectrum bactericidal properties in mice and do not induce the emergence of resistance. The oligomers contain acyl chains, which prevent the formation of stable secondary structure. This design appears advantageous over conventional antimicrobial peptides with respect to in vivo efficacy and safety, and may provide a convenient platform for the development of peptide antibiotics.
UR - http://www.scopus.com/inward/record.url?scp=34250157753&partnerID=8YFLogxK
U2 - 10.1038/nbt1309
DO - 10.1038/nbt1309
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C2 - 17529972
AN - SCOPUS:34250157753
SN - 1087-0156
VL - 25
SP - 657
EP - 659
JO - Nature Biotechnology
JF - Nature Biotechnology
IS - 6
ER -