Improved antimicrobial peptides based on acyl-lysine oligomers

Inna S. Radzishevsky, Shahar Rotem, Dmitry Bourdetsky, Shiri Navon-Venezia, Yehuda Carmeli, Amram Mor

Research output: Contribution to journalArticlepeer-review


We describe peptidomimetic oligomers that show rapid, nonhemolytic, broad-spectrum bactericidal properties in mice and do not induce the emergence of resistance. The oligomers contain acyl chains, which prevent the formation of stable secondary structure. This design appears advantageous over conventional antimicrobial peptides with respect to in vivo efficacy and safety, and may provide a convenient platform for the development of peptide antibiotics.

Original languageEnglish
Pages (from-to)657-659
Number of pages3
JournalNature Biotechnology
Issue number6
StatePublished - Jun 2007
Externally publishedYes


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