Implications of the expression of myeloid markers on normal and leukemic stem cells

Daniel J. Pearce, David C. Taussig, Dominique Bonnet

Research output: Contribution to journalShort surveypeer-review

Abstract

We have recently described the expression of CD33 and other antigens previously thought to be myeloid specific on both acute myeloid leukemia-initiating cells (AML-IC) and normal hematopoietic stem cells (HSC) that are capable of repopulating immuno-deficient mice. Here, we discuss that the presence of myeloid markers on AML-ICs and HSCs makes identification of an antigen for targeted therapy extremely difficult. Xenotransplantation assays should be used wherever possible to test the suitability of candidate antigens for targeted therapy, including the assessment of the effect on normal cells.

Original languageEnglish
Pages (from-to)271-273
Number of pages3
JournalCell Cycle
Volume5
Issue number3
DOIs
StatePublished - 1 Feb 2006

Fingerprint

Dive into the research topics of 'Implications of the expression of myeloid markers on normal and leukemic stem cells'. Together they form a unique fingerprint.

Cite this