Implications of Plasma Levels of Catechols in the Evaluation of SympathoadrenomeduUary Function

David S. Goldstein*, Graeme Eisenhower, Moshe Garty, Carol J. Folio, Robin Stull, John E. Brush, Frederic L. Sax, Harry R. Keiser, Irwin J. Kopin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


This report summarizes new techniques for examining aspects of sympathoadrenomedullary function. Tracer pharmacokinetic methods are more accurate than measurements of antecubital venous norepinephrine (NE) in assessing sympathoneural responsiveness. During mental challenge (playing a video game), patients with essential hypertension had significantly larger increments of NE spillover into arterial blood than did normotensive control subjects, whereas responses of antecubital venous and even arterial NE did not differ significantly between the groups. The rate of neuronal reuptake of endogenous NE can be measured in vivo using plasma levels of NE and of the intraneuronal NE metabolite, dihydroxyphenylglycol (DHPG). Regional production of dihydroxyphenylalanine (DOPA) may reflect catecholamine biosynthesis, and DOPA may be an indirectly acting natriuretic neurohormone. Positron emission tomography after injection of positron-emitting fluorodopamine may allow in vivo, noninvasive assessments of regional sympathetic function. Am J Hypertens 1989;2:133S-139S.

Original languageEnglish
Pages (from-to)133S-139S
JournalAmerican Journal of Hypertension
Issue number3
StatePublished - Mar 1989
Externally publishedYes


  • DOPA
  • Dihydroxyphenylglycol
  • Dopamine
  • Epinephrine
  • Hypertension
  • Norepinephrine
  • Sympathetic nervous system


Dive into the research topics of 'Implications of Plasma Levels of Catechols in the Evaluation of SympathoadrenomeduUary Function'. Together they form a unique fingerprint.

Cite this