Within the four-generation standard model, the Higgs couplings to gluons and to photons deviate in a significant way from the predictions of the three-generation standard model. As a consequence, large departures in several Higgs production and decay channels are expected. Recent Higgs search results, presented by ATLAS, CMS, and CDF, hint on the existence of a Higgs boson with a mass around 125 GeV. Using these results and assuming such a Higgs boson, we derive exclusion limits on the four-generation standard model. For m H=125 GeV, the model is excluded above 99.95% confidence level. For 124.5 GeV≤mH≤127.5 GeV, an exclusion limit above 99% confidence level is found.