Impaired water homeostasis following mixed carbamazepine and phenobarbital overdose

Oz M. Shapira; Steven Feld; Eitan Mor; Sergio Konichezky

doi:10.1177/106002809102500404

Impaired water homeostasis following mixed carbamazepine and phenobarbital overdose

Oz M. Shapira^*, Steven Feld, Eitan Mor, Sergio Konichezky

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Both carbamazepine and phenobarbital are known to have antidiuretic properties when administered chronically. We describe a case of acute impairment of body water homeostasis following mixed drug overdose with carbamazepine and phenobarbital. Serum carbamazepine concentrations correlated with alternating states of diuresis and antidiuresis. We recommend close monitoring of fluid and electrolyte status in carbamazepine overdose.

Original language	English
Pages (from-to)	354-356
Number of pages	3
Journal	Annals of Pharmacotherapy
Volume	25
Issue number	4
DOIs	https://doi.org/10.1177/106002809102500404
State	Published - Apr 1991
Externally published	Yes

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abstract = "Both carbamazepine and phenobarbital are known to have antidiuretic properties when administered chronically. We describe a case of acute impairment of body water homeostasis following mixed drug overdose with carbamazepine and phenobarbital. Serum carbamazepine concentrations correlated with alternating states of diuresis and antidiuresis. We recommend close monitoring of fluid and electrolyte status in carbamazepine overdose.",

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Impaired water homeostasis following mixed carbamazepine and phenobarbital overdose

Abstract

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