Impaired lymphocyte reconstitution after autologous transplant is associated with apoptosis of CD8+ T cells and adverse clinical outcome

Uri Rozovski, Ella Naparstek, Shani Frank, Alexey Fourman, Eti Zigman-Hoffman, Margalit Bleiberg, Moshe Yeshurun, Svetlana Trestman, Boris Tartakovsky

Research output: Contribution to journalArticlepeer-review

Abstract

We noticed that the lymphocyte counts, after autologous hematopoietic stem cell transplantation, oscillated during the first 4 post-transplant months. Thereafter, the lymphocyte counts stabilized and segregated the patients into two groups, those who normalized their lymphocyte counts and those with prolonged lymphopenia. In both groups, the CD4 counts remained low for at least 6 months. However, in approximately half of the patient, the CD8 counts increased to normal or above normal values. Patients with prolonged lymphopenia had higher rates of lymphocytes’ spontaneous apoptosis and the lymphocytes in patients who restored their counts expressed the intracellular CD14-derived MO2 epitope that protects the cells from apoptosis. These findings were translated to longer disease-free survival and overall survival in patients who restored the CD8 counts. Collectively, our data show that post-transplant lymphocytes that express intracellular CD14-MO2 epitope have survival advantage.

Original languageEnglish
Pages (from-to)2264-2270
Number of pages7
JournalLeukemia and Lymphoma
Volume60
Issue number9
DOIs
StatePublished - 29 Jul 2019
Externally publishedYes

Keywords

  • Lymphocytes
  • basic biology
  • cell cycle and apoptosis changes

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