@article{c4297f106dad4038b5670f3937572618,
title = "Impact of the Cultivation Technique on the Production of Secondary Metabolites by Chrysosporium lobatum TM-237-S5, Isolated from the Sponge Acanthella cavernosa",
abstract = "The fungi Chrysosporium lobatum TM-237-S5 was isolated from the sponge Acanthella cavernosa, collected from the mesophotic coral ecosystem of the Red Sea. The strain was cultivated on a potato dextrose agar (PDA) medium, coupling solid-state fermentation and solid-state extraction (SSF/SSE) with a neutral macroreticular polymeric adsorbent XAD Amberlite resin (AMBERLITE XAD1600N). The SSF/SSE lead to high chemodiversity and productivity compared to classical submerged cultivation. Ten phenalenone related compounds were isolated and fully characterized by one-dimensional and two-dimensional NMR and HRMS. Among them, four were found to be new compounds corresponding to isoconiolactone, (-)-peniciphenalenin F, (+)-8-hydroxyscleroderodin, and (+)-8-hydroxysclerodin. It is concluded that SSF/SSE is a powerful strategy, opening a new era for the exploitation of microbial secondary metabolites.",
keywords = "Chrysosporium lobatum, Marine fungi, Phenalenone derivatives, Solid-state extraction, Solid-state fermentation",
author = "{Le Goff}, G{\'e}raldine and Philippe Lopes and Guillaume Arcile and Pinelopi Vlachou and Elslande, {Elsa Van} and Pascal Retailleau and Gallard, {Jean Fran{\c c}ois} and Michal Weis and Yehuda Benayahu and Nikolas Fokialakis and Jamal Ouazzani",
note = "Publisher Copyright: {\textcopyright} 2019 by the authors.",
year = "2019",
doi = "10.3390/md17120678",
language = "אנגלית",
volume = "17",
journal = "Marine Drugs",
issn = "1660-3397",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "12",
}