TY - JOUR
T1 - Impact of Platelet-Rich Plasma on Arthroscopic Repair of Small- to Medium-Sized Rotator Cuff Tears
T2 - A Randomized Controlled Trial
AU - Holtby, Richard
AU - Christakis, Monique
AU - Maman, Eran
AU - MacDermid, Joy C.
AU - Dwyer, Tim
AU - Athwal, George S.
AU - Faber, Kenneth
AU - Theodoropoulos, John
AU - Woodhouse, Linda J.
AU - Razmjou, Helen
N1 - Publisher Copyright:
© 2016, © The Author(s) 2016.
PY - 2016/9/13
Y1 - 2016/9/13
N2 - Background: Increased interest in using platelet-rich plasma (PRP) as an augment to rotator cuff repair warrants further investigation, particularly in smaller rotator cuff tears. Purpose: To examine the effectiveness of PRP application in improving perioperative pain and function and promoting healing at 6 months after arthroscopic repair of small- or medium-sized rotator cuff tears. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: This was a double-blinded randomized controlled trial of patients undergoing arthroscopic repair of partial- or full-thickness rotator cuff tears of up to 3 cm who were observed for 6 months. Patients were randomized to either repair and PRP application (study group) or repair only (control group) groups. The patient-oriented outcome measures utilized were the visual analog scale (VAS), the Short Western Ontario Rotator Cuff Index (ShortWORC), the American Shoulder and Elbow Surgeons (ASES) form, and the Constant-Murley Score (CMS). Range of motion (ROM) and inflammatory and coagulation markers were measured before and after surgery. Magnetic resonance imaging was used at 6 months to assess retear and fatty infiltration rate. Results: Eighty-two patients (41 males) with a mean age of 59 ± 8 years were enrolled; 41 patients were included in each group. Both the PRP and control groups showed a significant improvement in their pain level based on the VAS within the first 30 days (P <.0001), with the PRP group reporting less pain than the control group (P =.012), which was clinically significantly different from days 8 through 11. The PRP group reported taking less painkillers (P =.026) than the control group within the first 30 days. All outcome measure scores and ROM improved significantly after surgery (P <.0001), with no between-group differences. No differences were observed between groups in inflammatory or coagulation marker test results (P >.05), retear (14% vs 18% full retear; P =.44), or fatty infiltration rate (P =.08). Conclusion: The PRP biological augmentation for repair of small- to medium-sized rotator cuff tears has a short-term effect on perioperative pain without any significant impact on patient-oriented outcome measures or structural integrity of the repair compared with control group.
AB - Background: Increased interest in using platelet-rich plasma (PRP) as an augment to rotator cuff repair warrants further investigation, particularly in smaller rotator cuff tears. Purpose: To examine the effectiveness of PRP application in improving perioperative pain and function and promoting healing at 6 months after arthroscopic repair of small- or medium-sized rotator cuff tears. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: This was a double-blinded randomized controlled trial of patients undergoing arthroscopic repair of partial- or full-thickness rotator cuff tears of up to 3 cm who were observed for 6 months. Patients were randomized to either repair and PRP application (study group) or repair only (control group) groups. The patient-oriented outcome measures utilized were the visual analog scale (VAS), the Short Western Ontario Rotator Cuff Index (ShortWORC), the American Shoulder and Elbow Surgeons (ASES) form, and the Constant-Murley Score (CMS). Range of motion (ROM) and inflammatory and coagulation markers were measured before and after surgery. Magnetic resonance imaging was used at 6 months to assess retear and fatty infiltration rate. Results: Eighty-two patients (41 males) with a mean age of 59 ± 8 years were enrolled; 41 patients were included in each group. Both the PRP and control groups showed a significant improvement in their pain level based on the VAS within the first 30 days (P <.0001), with the PRP group reporting less pain than the control group (P =.012), which was clinically significantly different from days 8 through 11. The PRP group reported taking less painkillers (P =.026) than the control group within the first 30 days. All outcome measure scores and ROM improved significantly after surgery (P <.0001), with no between-group differences. No differences were observed between groups in inflammatory or coagulation marker test results (P >.05), retear (14% vs 18% full retear; P =.44), or fatty infiltration rate (P =.08). Conclusion: The PRP biological augmentation for repair of small- to medium-sized rotator cuff tears has a short-term effect on perioperative pain without any significant impact on patient-oriented outcome measures or structural integrity of the repair compared with control group.
KW - healing
KW - platelet-rich plasma
KW - rotator cuff
UR - http://www.scopus.com/inward/record.url?scp=84989814785&partnerID=8YFLogxK
U2 - 10.1177/2325967116665595
DO - 10.1177/2325967116665595
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AN - SCOPUS:84989814785
SN - 2325-9671
VL - 4
JO - Orthopaedic Journal of Sports Medicine
JF - Orthopaedic Journal of Sports Medicine
IS - 9
ER -