Impact of obstructive sleep apnea on left ventricular mass and diastolic function

Mitra Niroumand, Raffael Kuperstein, Zion Sasson, Patrick J. Hanly*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

136 Scopus citations

Abstract

We wished to determine if obstructive sleep apnea (OSA) is associated with increased left ventricular mass (LVM) and impaired left ventricular diastolic function (LVDF) independently of coexisting obesity, hypertension (HTN), and diabetes mellitus (DM). Patients without primary cardiac disease, referred for evaluation of OSA (n = 533), had overnight polysomnography and Doppler echocardiography while awake. Patients were divided, according to the apnea-hypopnea index (AHI), into an OSA group (AHI ≥ 5/h, n = 353) and a non-OSA group (AHI < 5/h, n = 180). In men, LVM was greater in the OSA group (98.9 ± 25.6 versus 92.3 ± 22.5 g/m, p = 0.023) despite exclusion of those with HTN and DM. A similar trend was noted in women. Regression analysis revealed that LVM was correlated with body mass index (BMI) (β = 0.480, p 0.0005), age (β = 0.16, p = 0.001), and the presence of HTN (β = 0.137, p = 0.003) in men and with BMI (β = 0.501, p < 0.0005) in women, but not with AHI or oxygen saturation during sleep. The ratio of peak early filling velocity to peak late filling velocity (E/A), an index of LVDF, was similar in both groups (1.28 ± 0.32 versus 1.34 ± 0.31, p = 0.058); it was correlated with age (β = -0.474, p < 0.0005), but not with AHI or oxygen saturation during sleep. We conclude that OSA is not associated with increased LVM or impaired LVDF independently of obesity, HTN, or advancing age.

Original languageEnglish
Pages (from-to)1632-1636
Number of pages5
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume163
Issue number7
DOIs
StatePublished - 2001
Externally publishedYes

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