TY - JOUR
T1 - Impact of obstructive sleep apnea on left ventricular mass and diastolic function
AU - Niroumand, Mitra
AU - Kuperstein, Raffael
AU - Sasson, Zion
AU - Hanly, Patrick J.
PY - 2001
Y1 - 2001
N2 - We wished to determine if obstructive sleep apnea (OSA) is associated with increased left ventricular mass (LVM) and impaired left ventricular diastolic function (LVDF) independently of coexisting obesity, hypertension (HTN), and diabetes mellitus (DM). Patients without primary cardiac disease, referred for evaluation of OSA (n = 533), had overnight polysomnography and Doppler echocardiography while awake. Patients were divided, according to the apnea-hypopnea index (AHI), into an OSA group (AHI ≥ 5/h, n = 353) and a non-OSA group (AHI < 5/h, n = 180). In men, LVM was greater in the OSA group (98.9 ± 25.6 versus 92.3 ± 22.5 g/m, p = 0.023) despite exclusion of those with HTN and DM. A similar trend was noted in women. Regression analysis revealed that LVM was correlated with body mass index (BMI) (β = 0.480, p 0.0005), age (β = 0.16, p = 0.001), and the presence of HTN (β = 0.137, p = 0.003) in men and with BMI (β = 0.501, p < 0.0005) in women, but not with AHI or oxygen saturation during sleep. The ratio of peak early filling velocity to peak late filling velocity (E/A), an index of LVDF, was similar in both groups (1.28 ± 0.32 versus 1.34 ± 0.31, p = 0.058); it was correlated with age (β = -0.474, p < 0.0005), but not with AHI or oxygen saturation during sleep. We conclude that OSA is not associated with increased LVM or impaired LVDF independently of obesity, HTN, or advancing age.
AB - We wished to determine if obstructive sleep apnea (OSA) is associated with increased left ventricular mass (LVM) and impaired left ventricular diastolic function (LVDF) independently of coexisting obesity, hypertension (HTN), and diabetes mellitus (DM). Patients without primary cardiac disease, referred for evaluation of OSA (n = 533), had overnight polysomnography and Doppler echocardiography while awake. Patients were divided, according to the apnea-hypopnea index (AHI), into an OSA group (AHI ≥ 5/h, n = 353) and a non-OSA group (AHI < 5/h, n = 180). In men, LVM was greater in the OSA group (98.9 ± 25.6 versus 92.3 ± 22.5 g/m, p = 0.023) despite exclusion of those with HTN and DM. A similar trend was noted in women. Regression analysis revealed that LVM was correlated with body mass index (BMI) (β = 0.480, p 0.0005), age (β = 0.16, p = 0.001), and the presence of HTN (β = 0.137, p = 0.003) in men and with BMI (β = 0.501, p < 0.0005) in women, but not with AHI or oxygen saturation during sleep. The ratio of peak early filling velocity to peak late filling velocity (E/A), an index of LVDF, was similar in both groups (1.28 ± 0.32 versus 1.34 ± 0.31, p = 0.058); it was correlated with age (β = -0.474, p < 0.0005), but not with AHI or oxygen saturation during sleep. We conclude that OSA is not associated with increased LVM or impaired LVDF independently of obesity, HTN, or advancing age.
UR - http://www.scopus.com/inward/record.url?scp=0034954439&partnerID=8YFLogxK
U2 - 10.1164/ajrccm.163.7.2007014
DO - 10.1164/ajrccm.163.7.2007014
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 11401886
AN - SCOPUS:0034954439
SN - 1073-449X
VL - 163
SP - 1632
EP - 1636
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
IS - 7
ER -