Impact of intramural non-cavity-distorting leiomyoma on placental histopathology and perinatal outcome in singleton live births resulting from in vitro fertilization treatment

Alexander Volodarsky-Perel*, Tuyet Nhung Ton Nu, Togas Tulandi, William Buckett, Yaron Gil, Alexandre Machado-Gedeon, Yiming Cui, Jonathan Shaul, Michael H. Dahan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To evaluate the effect of non-cavity-distorting intramural leiomyomas on the placental histopathology pattern and perinatal outcome in singleton live births resulting from in vitro fertilization treatment. Methods: The study population included all singleton live births following in vitro fertilization treatment with autologous oocytes during the period from 2009 to 2017. Primary outcomes included anatomical, inflammation, vascular malperfusion, and villous maturation placental features. Secondary outcomes included fetal, maternal, delivery, and perinatal complications. Results: A total of 1119 live births were included in the final analysis and were allocated to the group of pregnancies with non-cavity-distorting intramural myomas (n = 101) and without myomas (n = 1018). After the adjustment for confounding factors, the non-cavity-distorting intramural myomas were found to be significantly associated with assisted placental delivery (OR 2.4; 95% CI 1.5–3.9), furcate cord insertion (OR 3.6; 95% CI 1.4–9.3), circumvallate membranes insertion (OR 5.2; 95% CI 1.4–19.3), chronic deciduitis (OR 8.2; 95% CI 1.6–42.2), focal intramural fibrin deposition (OR 25.1; 95% CI 2.1–306.2), subchorionic thrombi (OR 3.6; 95% CI 1.7–7.6), maternal vasculopathy (OR 2.5; 95% CI 1.2–5.5), and chorangioma (OR 5.9; 95% CI 1.4–25.2) as well as with the failure of labor progress (OR 2.4; 95% CI 1.3–4.4) and induction (OR 3.2; 95% CI 1.2–9.0). Conclusion: Intramural non-cavity-distorting myomas have a significant impact on the placental histopathology with a higher incidence of dysfunctional labor.

Original languageEnglish
Pages (from-to)1963-1974
Number of pages12
JournalJournal of Assisted Reproduction and Genetics
Volume37
Issue number8
DOIs
StatePublished - 1 Aug 2020
Externally publishedYes

Funding

FundersFunder number
McGill University

    Keywords

    • Dysfunctional labor
    • Histopathology
    • Intramural myoma
    • Placenta
    • Uterine cavity

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