Impact of dialysis type on outcome of acute renal failure in children: A single-center experience

Irit Krause*, Naama Herman, Roxana Cleper, Abigail Fraser, Miriam Davidovits

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Acute renal failure (ARF) is a common complication in critically ill children. It is known as an important predictor of morbidity and mortality in this population. Data on the factors affecting the choice of renal replacement therapy (RRT) modality and its impact on mortality of children with ARF are limited. Objectives: We retrospectively studied 115 children with ARF necessitating RRT during the period 1995-2005 to evaluate the effect of several prognostic factors as well as RRT type on their immediate outcome. Methods: The data collected from charts included demographics, primary disease, accompanying medical conditions, use of vasopressor support, indications for dialysis, RRT modality, and complications of dialysis. Categorical variables were analyzed using chi-square or Fisher's exact tests. Variables associated with mortality (P 〈 0.1) at the univariable level were studied by a multivariable logistic regression model. results: The most common cause of ARF was congenital heart disease (n=75). RRT modalities included peritoneal dialysis (PD) (n=81), hemodialfltration (HDF) (n=31) and intermittent hemodialysis (IHD) (n=18). Median RRT duration was 4 days (range 1-63 days). Overall mortality was 52.2%. IHD was associated with the best survival rate (P 〈 0.01 vs. PD and HDF), while children treated with HDF had the worse outcome. Hemodynamic instability and systemic infections were associated with greater mortality, but the rate of these complications did not differ between the study groups. Conclusions: Our results suggest that IHD when applied to the right patient in an appropriate setting may be a safe and efficient RRT modality in children with ARF. Randomized prospective trials are needed to further evaluate the impact of different RRT modalities on outcome in children with ARF.

Original languageEnglish
Pages (from-to)153-156
Number of pages4
JournalIsrael Medical Association Journal
Volume13
Issue number3
StatePublished - Mar 2011
Externally publishedYes

Keywords

  • Children
  • Hemodialfltration
  • Hemodialysis
  • Mortality
  • Peritoneal dialysis

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