Impact of circulating estradiol on melatonin binding sites in discrete areas of the female rat brain

Moshe Laudon, Nava Zisapel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The distribution of 125I-melatonin binding sites in 6 discrete brain regions of female rats at the estrous stage and the effects of ovariectomy and subsequent 17β-estradiol treatment on these binding sites were studied. Specific binding of 125I-melatonin was found in the hypothalamus, medulla-pons, hippocampus, cerebellum, striatum and parietal cortex of the female rats. Ovariectomy produced a large estradiol-reversible decrease in 125I-melatonin binding in the medulla-pons and hypothalamus. In contrast, 125I-melatonin binding sites in the other brain regions were generally unaffected by ovariectomy or estradiol. The estradiol-regulated changes in melatonin binding in the hypothalamus and medulla-pons may reflect the role of a specific estradiol-melatonin interaction in the coordination of the neuroendocrine reproductive axis.

Original languageEnglish
Pages (from-to)146-150
Number of pages5
JournalBrain Research
Volume402
Issue number1
DOIs
StatePublished - 27 Jan 1987

Keywords

  • Binding
  • Brain
  • Estradiol
  • Melatonin
  • Ovariectomy

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