@article{f3c3b02be1524b70bcb879172cee462a,
title = "Impact of circulating estradiol on melatonin binding sites in discrete areas of the female rat brain",
abstract = "The distribution of 125I-melatonin binding sites in 6 discrete brain regions of female rats at the estrous stage and the effects of ovariectomy and subsequent 17β-estradiol treatment on these binding sites were studied. Specific binding of 125I-melatonin was found in the hypothalamus, medulla-pons, hippocampus, cerebellum, striatum and parietal cortex of the female rats. Ovariectomy produced a large estradiol-reversible decrease in 125I-melatonin binding in the medulla-pons and hypothalamus. In contrast, 125I-melatonin binding sites in the other brain regions were generally unaffected by ovariectomy or estradiol. The estradiol-regulated changes in melatonin binding in the hypothalamus and medulla-pons may reflect the role of a specific estradiol-melatonin interaction in the coordination of the neuroendocrine reproductive axis.",
keywords = "Binding, Brain, Estradiol, Melatonin, Ovariectomy",
author = "Moshe Laudon and Nava Zisapel",
note = "Funding Information: This work was supported in part by the Israel Academy of Sciences and Humanities, Basic Research Foundation.",
year = "1987",
month = jan,
day = "27",
doi = "10.1016/0006-8993(87)91057-2",
language = "אנגלית",
volume = "402",
pages = "146--150",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier B.V.",
number = "1",
}