Impact of BRCA mutations on outcomes among patients with serous endometrial cancer

Yfat Kadan*, Oshrat Raviv, Yakir Segev, Ofer Lavie, Ilan Bruchim, Ami Fishman, Rachel Michaelson, Uzi Beller, Limor Helpman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To compare the outcome of patients with uterine papillary serous cancer (UPSC) carrying a BRCA mutation with that of patients with UPSC who are BRCA wild-type. Methods: The present retrospective, multicenter cohort study included women with UPSC who were diagnosed between January 1, 1993, and December 31, 2014, and were tested for the BRCA mutation at three Israeli medical centers. Data were collected from the medical records, and patient and tumor characteristics and disease outcomes were compared between BRCA mutation carriers and noncarriers. The primary outcome was overall survival. Results: In total, 14 BRCA mutation carriers and 50 noncarriers were included. Both groups had similar treatment modalities (P=0.530). A non-significant trend toward BRCA mutation carriers being diagnosed more frequently at an advanced stage compared with noncarriers was observed (P=0.090). Median overall survival (25 vs 37 months; P=0.442), progression-free survival (37 vs 29 months; P=0.536), and disease-specific survival (60 vs 39 months; P=0.316) were similar between the carrier and noncarrier groups. Conclusions: Although not significant, BRCA mutation carriers tended to have more advanced disease at diagnosis. However, the survival was similar irrespective of the BRCA status in this small group. Further research is needed to confirm these findings in a larger cohort.

Original languageEnglish
Pages (from-to)91-96
Number of pages6
JournalInternational Journal of Gynecology and Obstetrics
Volume142
Issue number1
DOIs
StatePublished - Jul 2018
Externally publishedYes

Keywords

  • BRCA mutation carriers
  • BRCA mutation non-carriers
  • Disease outcome
  • Overall survival
  • Progression-free survival
  • Uterine serous endometrial cancer

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