TY - JOUR
T1 - Immunotherapy of prostate cancer
AU - Freedland, Stephen J.
AU - Pantuck, Allan J.
AU - Weider, Jeffrey
AU - Zisman, Amnon
AU - Belldegrun, Arie S.
N1 - Publisher Copyright:
© 2001, Current Science Inc.
PY - 2001/5
Y1 - 2001/5
N2 - The realization that prostate cancer is an immunogenic tumor, in conjunction with the discovery of novel methods for priming the immune system to generate an antitumor response, has resulted in several new approaches for prostate cancer immunotherapy. Based on these various approaches, several human clinical trials have begun using immune-based therapies for prostate cancer. These approaches can be divided into cytokine-based therapies, tumor-associated antigen-based therapies, tumor vaccines, and dendritic cell-based therapies. This review summarizes the latest findings from each of these approaches and gives results from the few completed human clinical trials.
AB - The realization that prostate cancer is an immunogenic tumor, in conjunction with the discovery of novel methods for priming the immune system to generate an antitumor response, has resulted in several new approaches for prostate cancer immunotherapy. Based on these various approaches, several human clinical trials have begun using immune-based therapies for prostate cancer. These approaches can be divided into cytokine-based therapies, tumor-associated antigen-based therapies, tumor vaccines, and dendritic cell-based therapies. This review summarizes the latest findings from each of these approaches and gives results from the few completed human clinical trials.
KW - Dendritic Cell
KW - Epidermal Growth Factor Receptor
KW - Human Clinical Trial
KW - Prostatic Acid Phosphatase
KW - Tumor Vaccine
UR - http://www.scopus.com/inward/record.url?scp=0035372397&partnerID=8YFLogxK
U2 - 10.1007/s11934-001-0086-9
DO - 10.1007/s11934-001-0086-9
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C2 - 12084272
AN - SCOPUS:0035372397
SN - 1527-2737
VL - 2
SP - 242
EP - 247
JO - Current Urology Reports
JF - Current Urology Reports
IS - 3
ER -